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What resolves this contention: PV gain modulation: division vs subtraction / Atallah et al. 2012 (Neuron) reported that PV interneurons LINEARLY transform cortical responses—primarily multiplicative (divisive/contrast) gain control, with PV activation suppressing pyramidal firing proportionally. Wilson, Runyan, Wang & Sur 2012 (Nature) instead showed division by SST and subtraction by PV (i.e., PV produces ADDITIVE/subtractive inhibition while SST produces divisive). Later studies (Lee et al. 2012; Khan et al. 2018) and theory (Seybold et al.) reconciled the discrepancy in part by noting it depends on PV recruitment level, contrast regime, and feature specificity. / Atallah et al. 2012 (Neuron) reported that PV interneurons LINEARLY transform cortical responses—primarily multiplicative (divisive/contrast) gain control, with PV activation suppressing pyramidal firing proportionally. Wilson, Runyan, Wang & Sur 2012 (Nat
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May 16, 2026
Updated
May 17, 2026

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