What resolves this contention: VIP+ interneuron preservation in the 3xTg mouse…

What resolves this contention: VIP+ interneuron preservation in the 3xTg mouse model of AD (CA1 hippocampus, no significant change in cell counts) versus loss of Vip+ inhibitory subtypes in late-phase human AD middle temporal gyrus. The mouse model shows altered firing output without cell loss; the human data implicate cell-type vulnerability that emerges only in late disease. / Additionally, our findings revealed no disparity in either CR-INs or VIP subtype co-expressing CR and VIP and representing the I-S3 cells ( Figure 1c, d ; VIP-nonTg: n = 11 sections/3 animals; VIP-Tg: n = 11 sections/3 animals). / a later phase with exponential increase in pathology, loss of excitatory neurons and Pvalb+ and Vip+ inhibitory neuron subtypes.