What resolves this contention: Kasthuri 2015 concludes that physical proximity…

What resolves this contention: Kasthuri 2015 concludes that physical proximity is insufficient to predict whether two neurons form synapses, while Ding 2025 finds that axon–dendrite co-travel (a finer-grained proxy for opportunity) is itself a graded function of functional similarity. The two studies disagree on whether the opportunity-controlled signal in Peters' rule contains additional functional information; they use different graining of opportunity (every spine vs. ADP). / For example, by tracing the trajectories of all excitatory axons and noting their juxtapositions, both synaptic and non-synaptic, with every dendritic spine we refute the idea that physical proximity is sufficient to predict synaptic connectivity (the so-called Peters' rule). / Among pairs of neurons with at least one ADP, axon–dendrite co-travelling for longer-than-average distances was associated with higher-than-average feature similarity (