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What resolves this contention: Both studies argue that mouse ALM preparatory activity is not maintained by local recurrence alone but by a multi-region loop; they nonetheless implicate different external partners (thalamus vs. cerebellar nuclei). The relative contributions of thalamic versus cerebellar input to maintaining cortical persistent activity — and whether they act in parallel, serially, or as redundant supports — remain to be quantitatively dissected. / Photoinhibition of the thalamus caused a short-latency and near-complete collapse of ALM activity. / The silencing of frontal cortex activity abolished preparatory activity in the cerebellar nuclei, and fastigial activity was necessary to maintain cortical preparatory activity.
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May 16, 2026
Updated
May 17, 2026

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