What resolves this contention: The ectopic spiking study shows that optogenetic…

What resolves this contention: The ectopic spiking study shows that optogenetic activation of PV+ neurons causes ectopic action potentials from distal axonal sites, generating non-physiological activity patterns. This challenges the interpretation of optogenetic studies that use broad light stimulation of PV+ cells to study circuit function, including studies measuring PV-to-MC inhibition.