What resolves this contention: {'position': 'PV interneuron dysfunction is a primary developmental deficit in schizophrenia', 'evidence_description': 'Reduced PV and GAD67 found consistently across brain regions; developmental animal models recapitulate PV deficits; genetic risk factors converge on interneuron development pathways'} / {'position': 'PV/GAD67 changes may be secondary to altered cortical activity or medication', 'evidence_description': 'PV expression is activity-dependent; chronic stress reduces PV expression in animals; some studies find preserved PV neuron numbers with reduced PV protein; antipsychotic medication affects GABA markers'}
Replication
No replications yet
Discussion
No comments yet — be the first.