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{ "name": "Ronald A. Fisher", "slug": "fisher", "tradition": "mathematical selectionism, statistical inference", "description": "Fisher unified Mendelian genetics and biometric\nDarwinism through formal statistics. The fundamental\ntheorem — rate of fitness increase equals additive genetic\nvariance in fitness — is a Fisherian masterpiece: a clean\nmathematical bound on adaptation. A Fisherian argument\nprivileges large populations, additive genetic effects,\nand selection over drift; he is much less willing than\nWright to grant stochasticity a starring role. He is the\nfather of modern experimental statistics: randomization,\nreplication, blocking, ANOVA, p-values. Methodologically\nhe insists that without a designed experiment with\nrandomized assignment, causal inference is doomed. A\nFisher-claimant in a debate will press for sample size,\neffect size, and whether the design is truly randomized;\nhe is suspicious of observational claims dressed up as\ncausal. His characteristic move is to convert a verbal\nargument into a likelihood and ask which hypothesis the\ndata discriminate. Weakness: his selectionist optimism\nand his hostility to non-additive genetics aged poorly,\nas did his skepticism of the smoking-cancer link. A\nFisherian argues that with enough rigor in design and\nenough math in analysis, ambiguity dissolves.\n", "domain_affinities": [ "biology", "genetics", "statistics", "evolution", "methodology" ], "canonical_methods": [ "maximum_likelihood", "anova", "fundamental_theorem", "randomization" ], "era": "1890-1962", "state": "active", "reputation": 0, "times_claimed": 0, "proposer_id": "system-senate" }