Stimulus novelty uncovers coding diversity in survey of visual cortex

bioRxiv (Cold Spring Harbor Laboratory) 2023 34 cites
2023:32024:82025:112026:12
2023 2026
34

Garrett, Marina and Groblewski, Peter and Piet, Alex and Ollerenshaw, Doug and Najafi, Farzaneh and Yavorska, Iryna and Amster, Adam and Bennett, Corbett and Buice, Michael and Caldejon, Shiella and Casal, Linzy and D'Orazi, Florence and Daniel, Scott and de Vries, Saskia EJ and Kapner, Daniel and Kiggins, Justin and Lecoq, Jerome and Ledochowitsch, Peter and Manavi, Sahar and Mei, Nicholas and Morrison, Christopher B. and Naylor, Sarah and Orlova, Natalia and Perkins, Jed and Ponvert, Nick and Roll, Clark and Seid, Sam and Williams, Derric and Williford, Allison and Ahmed, Ruweida and Amine, Daniel and Billeh, Yazan and Bowman, Chris and Cain, Nicholas and Cho, Andrew and Dawe, Tim and Departee, Max and Desoto, Marie and Feng, David and Gale, Sam and Gelfand, Emily and Gradis, Nile and Grasso, Conor and Hancock, Nicole and Hu, Brian and Hytnen, Ross and Jia, Xiaoxuan and Johnson, Tye and Kato, India and Kivikas, Sara and Kuan, Leonard and L'Heureux, Quinn and Lambert, Sophie and Leon, Arielle and Liang, Elizabeth and Long, Fuhui and Mace, Kyla and de Abril, Ildefons Magrans and Mochizuki, Chris and Nayan, Chelsea and North, Katherine and Ng, Lydia and Ocker, Gabriel Koch and Oliver, Michael and Rhoads, Paul and Ronellenfitch, Kara and Schelonka, Kathryn and Sevigny, Josh and Sullivan, David and Sutton, Ben and Swapp, Jackie and Nguyen, Thuyanh K and Waughman, Xana and Wilkes, Joshua and Wang, Michael and Farrell, Colin and Wakeman, Wayne and Zeng, Hongkui and Phillips, John and Mihalas, Stefan and Arkhipov, Anton and Koch, Christof and Olsen, Shawn R

Abstract

Abstract Detecting novel stimuli in the environment is critical for learning and survival, yet the neural basis of novelty processing is not understood. To characterize cell type-specific novelty processing, we surveyed the activity of ∼15,000 excitatory and inhibitory neurons in mice performing a visual task with novel and familiar stimuli. Clustering revealed a dozen functional neuron types defined by experience-dependent encoding. Vasoactive-intestinal-peptide (Vip) expressing inhibitory neurons were diverse, encoding novel stimuli, omissions of familiar stimuli, or behavioral features. Distinct Somatostatin (Sst) expressing inhibitory neurons encoded either familiar or novel stimuli. Subsets of excitatory neurons co-clustered with specific Vip or Sst subpopulations, while Sst and Vip inhibitory clusters were non-overlapping. This study establishes that novelty processing is mediated by diverse functional neuron types in the visual cortex.

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