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{
  "pmid": "30529822",
  "doi": "10.1016/j.conb.2018.11.001",
  "abstract": "Experience leaves a lasting mark on neural circuit function in part through activity-regulated gene (ARG) expression. New genome wide approaches have revealed that ARG programs are highly cell-type-specific, raising the possibility that they mediate different forms of experience-dependent plasticity in different cell types. The cell-type specificity of these gene programs is achieved by a combination of cell-intrinsic mechanisms that determine the transcriptional response of each neuronal subtype to a given stimulus and by cell-extrinsic mechanisms that influence the nature of the stimulus a cell receives. A better understanding of these mechanisms could usher in an era of molecular systems neuroscience in which genetic perturbations of cell-type-specific plasticities are assessed using electrophysiology and in vivo imaging to reveal the neural basis of adaptive behaviors.",
  "journal": "Current opinion in neurobiology",
  "year": 2019,
  "authors": "Gray, Jesse M, Spiegel, Ivo",
  "mesh_terms": "[\"Gene Expression\", \"Neuronal Plasticity\", \"Neurons\", \"Transcription, Genetic\"]",
  "url": "https://doi.org/10.1016/j.conb.2018.11.001",
  "pmc_id": "",
  "external_ids": {
    "doi": "10.1016/j.conb.2018.11.001",
    "pmid": "30529822",
    "openalex": "https://openalex.org/W2903315203",
    "semantic_scholar": "e8863300afe24a244a585780b7f4ac955a37f8d7",
    "semantic_scholar_corpus_id": "54444486"
  },
  "citation_count": 35
}