All papers
- The unfolded protein response in the therapeutic effect of hydroxy-DHA against Alzheimer's disease.
The unfolded protein response (UPR) and autophagy are two cellular processes involved in the clearing of intracellular misfolded proteins. Both pathways are targets for molecules that may serve as treatments for several…
- 4-Hydroperoxy-2-decenoic acid ethyl ester protects against 6-hydroxydopamine-induced cell death via activation of Nrf2-ARE and eIF2α-ATF4 pathways.
Parkinson's disease (PD) is a neurodegenerative disorder characterized by progressive degeneration of dopaminergic neurons in the substantia nigra. Oxidative stress has been reported to be closely related to the pathogen…
- Microglia: A pharmacological target for the treatment of age-related cognitive decline and Alzheimer's disease.
As individuals age, microglia, the resident immune cells of the central nervous system (CNS), become less effective at preserving brain circuits. Increases in microglial inflammatory activity are thought to contribute to…
- The safety and efficacy of gamma frequency auditory and visual stimulation in the treatment of alzheimer's disease: a systematic review and meta-analysis.
Alzheimer's disease (AD) is a progressive neurodegenerative disorder associated with cognitive decline and significant global health burden. Current treatments offer limited benefits, highlighting the need for novel ther…
- The safety and effectiveness of 40 Hz γ-tACS in Alzheimer's disease: A meta-analysis.
The efficacy and safety of 40 Hz gamma transcranial alternating current stimulation (γ-tACS) in Alzheimer's disease (AD) are still uncertain. This meta-analysis was conducted to investigate the therapeutic potential and…
- Identifying large vessel occlusion at first glance in telemedicine.
Telemedicine has rapidly emerged as an important tool in emergency neurology. In particular, reliable biomarkers of large vessel occlusions (LVOs) are critically necessary in order to identify the need for in-hospital me…
- Acute TBK1/IKK-ε Inhibition Enhances the Generation of Disease-Associated Microglia-Like Phenotype Upon Cortical Stab-Wound Injury.
Traumatic brain injury has a poorer prognosis in elderly patients, possibly because of the enhanced inflammatory response characteristic of advanced age, known as "inflammaging." Recently, reduced activation of the TANK-…
- Frequency of Loss of Function Variants in LRRK2 in Parkinson Disease.
Pathogenic variants in LRRK2 are a relatively common genetic cause of Parkinson disease (PD). Currently, the molecular mechanism underlying disease is unknown, and gain and loss of function (LOF) models of pathogenesis h…
- Robot-assisted laparoscopic transplant-to-native ureteroureterostomy of an intraperitoneal renal allograft.
The objective is to describe our experience with robot-assisted laparoscopic transplant-to-native ureteroureterostomy (UU) in a pediatric patient with an intraperitoneal renal allograft. We have previously demonstrated t…
- Effects of focused ultrasound in a "clean" mouse model of ultrasonic neuromodulation.
Recent studies on ultrasonic neuromodulation (UNM) in rodents have shown that focused ultrasound (FUS) can activate peripheral auditory pathways, leading to off-target and brain-wide excitation, which obscures the direct…
- Correction to: Social and environmental determinants of child health in Mongolia across years of rapid economic growth: 2000-2010.
Unfortunately, after publication of this article [1], it was noticed that an error during the production process resulted in an incorrect author name. The author Semira Manaseki-Holland is incorrectly displayed as Semira…
- Moderate enhancement in tissue permeability by preclinical focused ultrasound.
10.1016/j.jconrel.2017.05.027
- Clinical Application of Plasma Neurofilament Light Chain in a Memory Clinic: A Pilot Study.
Neurofilament light chain (NfL) has been considered as a biomarker for neurodegenerative diseases including Alzheimer's disease (AD). We measured plasma NfL levels in older adults with cognitive complaints and evaluated…
- The NLRP3 inflammasome in Alzheimer's disease.
Innate immunity and inflammatory response plays an important role in the pathogenesis of Alzheimer's disease (AD). As the major resident immune cells in the brain, microglial cells constantly survey the microenvironment…
- Chronic Obstructive Pulmonary Disease: When Pulmonologists Do Something Good for the Heart.
10.1164/rccm.201512-2340ED
- Screening for Stereopsis of Children Using an Autostereoscopic Smartphone.
The advantage of using an autostereoscopic smartphone is that it can achieve 3D effects without the need for glasses. The purpose of this study was to evaluate whether this technology could be utilized to detect stereoac…
- Antiplatelet and anticoagulant effects of diterpenes isolated from the marine alga, Dictyota menstrualis.
Cardiovascular diseases represent a major cause of disability and death worldwide. Therapeutics are available, but they often have unsatisfactory results and may produce side effects. Alternative treatments based on the…
- EGF Suppresses the Initiation and Drives the Reversion of TGF-β1-induced Transition in Hepatic Oval Cells Showing the Plasticity of Progenitor Cells.
Transforming growth factor-β1 (TGF-β1) induces hepatic progenitors to tumor initiating cells through epithelial-mesenchymal transition (EMT), thus raising an important drawback for stem cell-based therapy. How to block a…
- Driving fast-spiking cells induces gamma rhythm and controls sensory responses.
Cortical gamma oscillations (20-80 Hz) predict increases in focused attention, and failure in gamma regulation is a hallmark of neurological and psychiatric disease. Current theory predicts that gamma oscillations are ge…
- Temporal Variations of Microbiota Associated with the Immature Stages of Two Florida Culex Mosquito Vectors.
Microbiota associated with mosquito vector populations impact several traits of mosquitoes, including survival, reproduction, control, and immunity against pathogens. The influence of seasonal variations and mosquito spe…
- A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid β.
Because it lacks a lymphatic circulation, the brain must clear extracellular proteins by an alternative mechanism. The cerebrospinal fluid (CSF) functions as a sink for brain extracellular solutes, but it is not clear ho…
- CRISPR Interference-Based Platform for Multimodal Genetic Screens in Human iPSC-Derived Neurons.
CRISPR/Cas9-based functional genomics have transformed our ability to elucidate mammalian cell biology. However, most previous CRISPR-based screens were conducted in cancer cell lines rather than healthy, differentiated…
- A longitudinal big data approach for precision health.
Precision health relies on the ability to assess disease risk at an individual level, detect early preclinical conditions and initiate preventive strategies. Recent technological advances in omics and wearable monitoring…
- The Effect of 40-Hz Light Therapy on Amyloid Load in Patients with Prodromal and Clinical Alzheimer's Disease.
Alzheimer's disease (AD) is a progressive neurodegenerative disorder. AD pathology is characterized by abnormal aggregation of the proteins amyloid-β (Aβ) and hyperphosphorylated tau. No effective disease modifying thera…
- A feasibility trial of gamma sensory flicker for patients with prodromal Alzheimer's disease.
We and collaborators discovered that flickering lights and sound at gamma frequency (40 Hz) reduce Alzheimer's disease (AD) pathology and alter immune cells and signaling in mice. To determine the feasibility of this int…