Alzheimer's Disease: Models and Molecular Mechanisms Informing Disease and Treatments.

Bioengineering (Basel) 2024

Nystuen KL, McNamee SM, Akula M, Holton KM, DeAngelis MM et al.

Abstract

Alzheimer’s Disease (AD) is a complex neurodegenerative disease resulting in progressive loss of memory, language and motor abilities caused by cortical and hippocampal degeneration. This review captures the landscape of understanding of AD pathology, diagnostics, and current therapies. Two major mechanisms direct AD pathology: (1) accumulation of amyloid β (Aβ) plaque and (2) tau-derived neurofibrillary tangles (NFT). The most common variants in the Aβ pathway in

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