The R136S mutation in the APOE3 gene confers resilience against tau pathology via inhibition of the cGAS-STING-IFN pathway.

2025

Abstract

Epub 2025 Jun 23. The R136S mutation in the APOE3 gene confers resilience against tau pathology via inhibition of the cGAS-STING-IFN pathway. Naguib S(1), Lopez-Lee C(2), Torres ER(1), Lee SI(1), Zhu J(1), Zhu D(1), Ye P(1), Norman K(1), Zhao M(1), Wong MY(1), Ambaw YA(3), Muñoz-Castañeda R(1), Wang W(1), Patel T(4), Bhagwat M(1), Norinsky R(5), Mok SA(4), Walther TC(6), Farese RV Jr(3), Luo W(1), Sinha SC(1), Wu Z(1), Fan L(1), Gong S(1), Gan L(7).

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