Ocular delivery of different valosin-containing protein (VCP) inhibitory formulations prevents retinal degeneration in rho(∆I255) mice.

J Control Release 2026

Cao B, Almansa-Garcia AC, Sen M, Mühlfriedel R, Seeliger MW et al.

Abstract

Rhodopsin-mediated autosomal dominant retinitis pigmentosa (RHO-adRP) is a progressive inherited retinal degenerative disorder currently lacking effective treatments. A recurrent 3-base pair deletion in the RHO gene, resulting in the loss of isoleucine at codon 255 or 256 (RHO

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