Cdkn2a/p16Ink4a loss impairs Spatial memory independently of Alzheimer's-associated genetic pathways in young adult mice.

Cell Mol Life Sci 2026

Stephan P, Plassard D, Keyes WM, Hérault Y

Abstract

BACKGROUND: The cyclin-dependent kinase inhibitor METHODS: Spatial learning and memory were assessed using the Morris Water Maze (MWM). Hippocampal transcriptomes from control, RESULTS: Loss of CONCLUSION: Constitutive SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00018-026-06079-3.

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