Cardiomyocyte-derived calcitonin regulates atrial fibrosis and AF.

Nature reviews. Cardiology 2021

Fernández-Ruiz I

Abstract

Comprehensive analysis of CRISPR off-target editing in neural tissues reveals higher rates of unintended modifications in post-mitotic neurons compared to dividing cells. Off-target effects persist permanently in non-dividing cells, raising significant safety concerns for CNS applications.

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