Version history

{
  "pmid": "24136970",
  "doi": "10.1126/science.1241224",
  "abstract": "1. Science. 2013 Oct 18;342(6156):373-7. doi: 10.1126/science.1241224.\n\nSleep drives metabolite clearance from the adult brain.\n\nXie L(1), Kang H, Xu Q, Chen MJ, Liao Y, Thiyagarajan M, O'Donnell J, \nChristensen DJ, Nicholson C, Iliff JJ, Takano T, Deane R, Nedergaard M.\n\nAuthor information:\n(1)Division of Glial Disease and Therapeutics, Center for Translational \nNeuromedicine, Department of Neurosurgery, University of Rochester Medical \nCenter, Rochester, NY 14642, USA.\n\nComment in\n    Science. 2013 Oct 18;342(6156):301. doi: 10.1126/science.342.6156.301.\n    Science. 2013 Oct 18;342(6156):316-7. doi: 10.1126/science.1245798.\n    Nat Rev Neurosci. 2013 Dec;14(12):816-7. doi: 10.1038/nrn3632.\n    Nat Rev Neurol. 2013 Dec;9(12):657. doi: 10.1038/nrneurol.2013.230.\n    Mov Disord. 2014 Jan;29(1):33. doi: 10.1002/mds.25765.\n    Neurosurgery. 2014 Feb;74(2):N17-8. doi: 10.1227/01.neu.0000442978.07078.e5.\n\nThe conservation of sleep across all animal species suggests that sleep serves a \nvital function. We here report that sleep has a critical function in ensuring \nmetabolic homeostasis. Using real-time assessments of tetramethylammonium \ndiffusion and two-photon imaging in live mice, we show that natural sleep or \nanesthesia are associated with a 60% increase in the interstitial space, \nresulting in a striking increase in convective exchange of cerebrospinal fluid \nwith interstitial fluid. In turn, convective fluxes of interstitial fluid \nincreased the rate of β-amyloid clearance during sleep. Thus, the restorative \nfunction of sleep may be a consequence of the enhanced removal of potentially \nneurotoxic waste products that accumulate in the awake central nervous system.\n\nDOI: 10.1126/science.1241224\nPMCID: PMC3880190\nPMID: 24136970 [Indexed for MEDLINE]",
  "journal": "Science",
  "year": 2013,
  "authors": "Xie L, Kang H, Xu Q, Chen MJ, Liao Y, Thiyagarajan M, O'Donnell J, Christensen DJ, Nicholson C, Iliff JJ",
  "url": "https://pubmed.ncbi.nlm.nih.gov/24136970",
  "external_ids": {
    "doi": "10.1126/science.1241224",
    "pmid": "24136970"
  },
  "citation_count": 1,
  "domain": "neurodegeneration"
}