Version history

{
  "pmid": "35642214",
  "doi": "10.2147/JIR.S350109",
  "abstract": "1. J Inflamm Res. 2022 May 25;15:3083-3094. doi: 10.2147/JIR.S350109. eCollection\n 2022.\n\nMicroglia-Mediated Neuroinflammation: A Potential Target for the Treatment of \nCardiovascular Diseases.\n\nWang M(#)(1)(2)(3), Pan W(#)(1)(2)(3), Xu Y(#)(1)(2)(3), Zhang J(1)(2)(3), Wan \nJ(1)(2)(3), Jiang H(1)(2)(3).\n\nAuthor information:\n(1)Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, 430060, \nPeople's Republic of China.\n(2)Cardiovascular Research Institute, Wuhan University, Wuhan, 430060, People's \nRepublic of China.\n(3)Hubei Key Laboratory of Cardiology, Wuhan, 430060, People's Republic of \nChina.\n(#)Contributed equally\n\nMicroglia are tissue-resident macrophages of the central nervous system (CNS). \nIn the CNS, microglia play an important role in the monitoring and intervention \nof synaptic and neuron-level activities. Interventions targeting microglia have \nbeen shown to improve the prognosis of various neurological diseases. Recently, \nstudies have observed the activation of microglia in different cardiovascular \ndiseases. In addition, different approaches that regulate the activity of \nmicroglia have been shown to modulate the incidence and progression of \ncardiovascular diseases. The change in autonomic nervous system activity after \nneuroinflammation may be a potential intermediate link between microglia and \ncardiovascular diseases. Here, in this review, we will discuss recent updates on \nthe regulatory role of microglia in hypertension, myocardial infarction and \nischemia/reperfusion injury. We propose that microglia serve as neuroimmune \nmodulators and potential targets for cardiovascular diseases.\n\n© 2022 Wang et al.\n\nDOI: 10.2147/JIR.S350109\nPMCID: PMC9148574\nPMID: 35642214\n\nConflict of interest statement: The authors declare that they have no competing \ninterests. References1.KapoorK, BhandareAM, FarnhamMMJ, et al. 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  "journal": "J Inflamm Res",
  "year": 2022,
  "authors": "Wang M, Pan W, Xu Y, Zhang J, Wan J, Jiang H",
  "url": "https://pubmed.ncbi.nlm.nih.gov/35642214",
  "external_ids": {
    "doi": "10.2147/JIR.S350109",
    "pmid": "35642214"
  },
  "citation_count": 1,
  "domain": "neurodegeneration"
}