Age-related immune dynamics in healthy adults revealed by longitudinal multi-omic profiling

Nature Immunology 2023

Abstract

Characterizing age-related changes in the immune system is essential for understanding susceptibility to infection and autoimmunity in older adults. We performed longitudinal multi-omic profiling of 1,020 healthy adults aged 20-89, measuring epigenomics, transcriptomics, proteomics, and immune cell phenotyping over two years. We identified age-associated immune signatures including inflammaging markers, thymic involution correlates, and clonal hematopoiesis patterns that stratify biological immune age independently of chronological age.

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