Axonally Transported Proteins in Axon Development, Maintenance, and Regeneration

Cold Spring Harbor Symposia on Quantitative Biology 1983 15 cites
1983:01984:11985:11986:11987:11988:11989:11990:21991:21992:21993:21994:1
1983 1994
15

Celia Baitinger, Richard E. Cheney, Dave Clements, Marcie A. Glicksman, Nobutaka Hirokawa, Joel M. Levine, Karina F. Meiri, Carolyn Simon et al.

Abstract

The static beauty of the structure of an axon belies its dynamic nature. An axon typically comprises a scaffolding of linear elements, the microtubules and neurofilaments, that are connected to each other and to the plasma membrane by a lattice of cross-linkers (Fig. 1). Embedded in this lattice, and communicating with the linear elements by additional cross-linkers, are membrane-bounded organelles (mitochondria and a variety of vesicular organelles). Smooth endoplasmic reticulum and F-actin microfilaments are often most concentrated beneath the axolemma. This picture of the axon represents the steady state of a system whose components are, in fact, in rapid flux. To appreciate the dynamic nature of the axon at a molecular level, the metabolic polarity of the axon can be exploited. Because the

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