Abstract 1071: Online resources from the Allen Institute for Immunology: longitudinal profiling of multiple myeloma treatment and the Human Immune System Explorer platform

Cancer Research 2025

Lucas T. Graybuck; Christian M. La France; Nicole Howard; Jessica Liang; Autumn Kelsey; Lauren Okada; Zachary Thomson; Aishwarya Chander; Patrick S. McGrath; Love Tӓtting; Yudong D. He; Emma L. Kuan; Marla C. Glass; Samir Rachid Zaim; Palak C. Genge; Medbh A. Dillon; Cole Phalen; Peter J. Wittig; Alexander T. Heubeck; Julian Reading; Charles R. Roll; Veronica Hernandez; Vaishnavi Parthasarathy; Tyanna Stuckey; Blessing Musgrove; Elliott Swanson; Morgan Weiss; Jessica Garber; Upaasana Krishnan; Yousef Aggoune; Madeline Ambrose; Aldan Beaubien; James Harvey; Neelima Inala; Ed Johnson; Stark Pister; Sathya Subramanian; Vitalii Tereshchenko; Anne Vetto; Xiaoling Song; Philip D. Greenberg; Ananda W. Goldrath; Mackenzie S. Kopp; Evan W. Newell; Damian J. Green; Troy R. Torgerson; Mary Kwok; Xiaojun Li; Melinda L. Angus-Hill; Paul Meijer

Abstract

Abstract The Allen Institute for Immunology was founded in 2018 to deeply profile the human immune system in health and disease. As part of our mission to understand how the immune system changes over time in the setting of oncology, we recruited a cohort of patients at diagnosis for multiple myeloma (MM), and followed these subjects throughout induction therapy, autologous stem cell transplant, and after transplant recovery. We sampled the same subjects longitudinally, then performed immune profiling using scRNA-seq on peripheral blood cells, CITE-seq on bone marrow cells, multiple high-dimensional flow cytometry panels, plasma and bone marrow interstitial fluid (BMIF) proteomics, and clinical lab tests. To process, analyze, and distribute this data, we developed the Human Immune System Explorer (HISE) platform, a flexible, scalable, cloud-based framework to enable storage, interactive analysis, visualization, and generation of Certificates of Reproducibility that enable inspection and replay of any step of an analysis workflow. We joined our robust, large-scale analytical platform to public-facing tools, scientific context, and data releases, which now include interactive visualization tools for exploring the effects of MM treatment in detail. We invite oncologists, immunologists, and clinicians to explore this resource and our expanding library of immunology data, insights, and tools at https://explore.allenimmunology.org/. Citation Format: Lucas Graybuck, Christian M. La France, Nicole Howard, Jessica Liang, Autumn Kelsey, Lauren Y. Okada, Zachary J. Thomson, Aishwarya Chander, Patrick I. McGrath, Love Tӓtting, Yudong D. He, Emma L. Kuan, Marla C. Glass, Samir Rachid Zaim, Palak C. Genge, Medbh A. Dillon, Cole G. Phalen, Peter J. Wittig, Alexander T. Heubeck, Julian Reading, Charles R. Roll, Veronica Hernandez, Vaishnavi Parthasarathy, Tyanna J. Stuckey, Blessing Musgrove, Elliott Swanson, Morgan D. Weiss, Jessica Garber, Upaasana Krishnan, Yousef Aggoune, Madeline Ambrose, Aldan Beaubien, James Harvey, Neelima Inala, Ed Johnson, Stark Pister, Sathya Subramanian, Vitalii Tereshchenko, Anne Vetto, Xiaoling Song, Philip D. Greenberg, Ananda W. Goldrath, Mackenzie S. Kopp, Evan W. Newell, Damian J. Green, Troy R. Torgerson, Mary Kwok, Xiao-jun Li, Melinda L. Angus-Hill, Paul Meijer. Online resources from the Allen Institute for Immunology: longitudinal profiling of multiple myeloma treatment and the Human Immune System Explorer platform [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2025; Part 1 (Regular Abstracts); 2025 Apr 25-30; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2025;85(8_Suppl_1):Abstract nr 1071.

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