Dynamics of human immune health across aging and infection

Nature 2025

Abstract

Understanding how the immune system evolves across the human lifespan and responds to acute perturbations such as infection is critical for designing effective vaccines and therapies for age-related diseases. Here we profiled immune responses to SARS-CoV-2 vaccination and infection across 1,000 individuals spanning ages 25-96 using multi-omic platforms including mass cytometry, transcriptomics, and proteomics, revealing age-associated immune remodeling patterns that predict vaccine responsiveness.

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