Circadian Clock Regulates Inflammation and the Development of Neurodegeneration.

Front Cell Infect Microbiol 2021

Wang XL, Li L

Abstract

  1. Front Cell Infect Microbiol. 2021 Sep 14;11:696554. doi: 10.3389/fcimb.2021.696554. eCollection 2021.

Circadian Clock Regulates Inflammation and the Development of Neurodegeneration.

Wang XL(1), Li L(2)(3).

Author information: (1)Department of Nephrology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. (2)Department of Surgery, Hubei Provincial Hospital of Traditional Chinese Medicine, Wuhan, China. (3)Hubei Province Academy of Traditional Chinese Medicine, Wuhan, China.

The circadian clock regulates numerous key physiological processes and maintains cellular, tissue, and systemic homeostasis. Disruption of circadian clock machinery influences key activities involved in immune response and brain function. Moreover, Immune activation has been closely linked to neurodegeneration. Here, we review the molecular clock machinery and the diurnal variation of immune activity. We summarize the circadian control of immunity in both central and peripheral immune cells, as well as the circadian regulation of brain cells that are implicated in neurodegeneration. We explore the important role of systemic inflammation on neurodegeneration. The circadian clock modulates cellular metabolism, which could be a mechanism underlying circadian control. We also discuss the circadian interventions implicated in inflammation and neurodegeneration. Targeting circadian clocks could be a potential strategy for the prevention and treatment of inflammation and neurodegenerative diseases.

Copyright © 2021 Wang and Li.

DOI: 10.3389/fcimb.2021.696554 PMCID: PMC8476957 PMID: 34595127 [Indexed for MEDLINE]

Conflict of interest statement: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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