Therapeutic targeting of lncRNAs in age-related ocular disease.

Experimental eye research 2026

Wang L, Wang Z

Abstract

Age-related ocular diseases, including age-related macular degeneration, cataract, and glaucoma, are significant causes of visual loss and blindness worldwide. Long non-coding RNAs (lncRNAs) participate in gene regulation, epigenetic control, and cellular homeostasis, and increasing evidence implicates them in age-related ocular disorders by modulating oxidative stress, inflammation, angiogenesis, apoptosis, and extracellular matrix remodeling within ocular tissues. LncRNAs are linked to retinal degeneration, lens opacity, and optic nerve damage, supporting their promise as biomarkers and targets for treatment approaches. This review summarizes current understanding of lncRNA-related processes in age-related ocular disease and emphasizes their potential roles in diagnosis, prognosis, and treatment. An integrated view of lncRNA function in aging ocular tissues may guide precision medicine strategies to prevent or slow vision loss in older individuals.

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