sTREM2 cerebrospinal fluid levels are a potential biomarker for microglia activity in early-stage Alzheimer's disease and associate with neuronal injury markers

EMBO Molecular Medicine 2016

Suárez-Calvet M, Kleinberger G, Araque Caballero MÁ, et al.

Abstract

Suárez-Calvet et al. found that soluble TREM2 (sTREM2) in cerebrospinal fluid peaks during early symptomatic stages of Alzheimer’s disease and correlates with biomarkers of neuronal injury (total tau, phospho-tau, neurofilament light). sTREM2 increases with age, suggesting age-related changes in TREM2 processing and microglial activation.

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