Abstract
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Nat Chem Biol. 2021 Apr;17(4):465-476. doi: 10.1038/s41589-020-00734-x. Epub 2021 Feb 4.
Phospholipase iPLA(2)β averts ferroptosis by eliminating a redox lipid death signal.
Sun WY(1)(2)(3), Tyurin VA(1), Mikulska-Ruminska K(4)(5), Shrivastava IH(1)(5), Anthonymuthu TS(1)(6), Zhai YJ(2)(3), Pan MH(2)(3), Gong HB(2)(3), Lu DH(2)(3), Sun J(2)(3), Duan WJ(2)(3), Korolev S(7), Abramov AY(8), Angelova PR(8), Miller I(7), Beharier O(9), Mao GW(1), Dar HH(1), Kapralov AA(1), Amoscato AA(1), Hastings TG(10), Greenamyre TJ(10), Chu CT(11), Sadovsky Y(9), Bahar I(5), Bayır H(1)(6), Tyurina YY(12), He RR(13)(14), Kagan VE(15)(16)(17)(18)(19).
Author information: (1)Department of Environmental and Occupational Health and Center for Free Radical and Antioxidant Health, University of Pittsburgh, Pittsburgh, PA, USA. (2)Guangdong Engineering Research Center of Chinese Medicine & Disease Susceptibility, Jinan University, Guangzhou, China. (3)International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Chinese Ministry of Education (MoE), College of Pharmacy, Jinan University, Guangzhou, China. (4)Institute of Physics, Faculty of Physics, Astronomy and Informatics, Nicolaus Copernicus University in Toruń, Toruń, Poland. (5)Department of Computational and Systems Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA. (6)Department of Critical Care Medicine, Safar Center for Resuscitation Research, Children’s Neuroscience Institute, Children’s Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, PA, USA. (7)Edward A. Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, St. Louis, MO, USA. (8)UCL Queen Square Institute of Neurology, Department of Clinical and Movement Neurosciences, University College London, Queen Square, London, UK. (9)Magee-Womens Research Institute and Department of OBGYN, University of Pittsburgh, Pittsburgh,