Abstract
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Cell Stem Cell. 2021 Sep 2;28(9):1533-1548.e6. doi: 10.1016/j.stem.2021.04.004. Epub 2021 Apr 27.
Age-dependent instability of mature neuronal fate in induced neurons from Alzheimer’s patients.
Mertens J(1), Herdy JR(2), Traxler L(3), Schafer ST(4), Schlachetzki JCM(5), Böhnke L(3), Reid DA(4), Lee H(4), Zangwill D(4), Fernandes DP(4), Agarwal RK(4), Lucciola R(4), Zhou-Yang L(6), Karbacher L(6), Edenhofer F(7), Stern S(8), Horvath S(9), Paquola ACM(10), Glass CK(5), Yuan SH(11), Ku M(12), Szücs A(13), Goldstein LSB(14), Galasko D(15), Gage FH(16).
Author information: (1)Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, CA, USA; Neural Aging Laboratory, Institute of Molecular Biology, CMBI, Leopold-Franzens-University Innsbruck, Tyrol, Austria. Electronic address: jerome.mertens@uibk.ac.at. (2)Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, CA, USA; Neural Aging Laboratory, Institute of Molecular Biology, CMBI, Leopold-Franzens-University Innsbruck, Tyrol, Austria; Department of Neurosciences, University of California, San Diego, La Jolla, CA, USA. (3)Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, CA, USA; Neural Aging Laboratory, Institute of Molecular Biology, CMBI, Leopold-Franzens-University Innsbruck, Tyrol, Austria. (4)Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, CA, USA. (5)Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA, USA. (6)Neural Aging Laboratory, Institute of Molecular Biology, CMBI, Leopold-Franzens-University Innsbruck, Tyrol, Austria. (7)Department of Genomics, Stem Cells & Regenerative Medicine, Institute of Molecular Biology, CMBI, Institute of Molecular Biology and CMBI, Leopold-Franzens-University Innsbruck, Tyrol, Austria. (8)Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, CA, USA; Sagol Department of Neurobiology, Faculty of