Neurodegeneration and the Circadian Clock.

Front Aging Neurosci 2017

Hood S, Amir S

Abstract

  1. Front Aging Neurosci. 2017 May 30;9:170. doi: 10.3389/fnagi.2017.00170. eCollection 2017.

Neurodegeneration and the Circadian Clock.

Hood S(1), Amir S(2).

Author information: (1)Department of Psychology, Bishop’s UniversitySherbrooke, QC, Canada. (2)Department of Psychology, Concordia UniversityMontreal, QC, Canada.

Despite varied etiologies and symptoms, several neurodegenerative diseases-specifically, Alzheimer’s (AD), Parkinson’s (PD), and Huntington’s diseases (HDs)-share the common feature of abnormal circadian rhythms, such as those in behavior (e.g., disrupted sleep/wake cycles), physiological processes (e.g., diminished hormone release) and biochemical activities (e.g., antioxidant production). Circadian disturbances are among the earliest symptoms of these diseases, and the molecular mechanisms of the circadian system are suspected to play a pivotal, and possibly causal, role in their natural histories. Here, we review the common circadian abnormalities observed in ADs, PDs and HDs, and summarize the evidence that the molecular circadian clockwork directly influences the course of these disease states. On the basis of this research, we explore several circadian-oriented interventions proposed as treatments for these neurological disorders.

DOI: 10.3389/fnagi.2017.00170 PMCID: PMC5447688 PMID: 28611660

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