Polystyrene nanoplastic exposure induces excessive mitophagy by activating AMPK/ULK1 pathway in differentiated SH-SY5Y cells and dopaminergic neurons in vivo.

Part Fibre Toxicol 2023

Huang Y, Liang B, Li Z

Abstract

  1. Part Fibre Toxicol. 2023 Nov 22;20(1):44. doi: 10.1186/s12989-023-00556-4.

Polystyrene nanoplastic exposure induces excessive mitophagy by activating AMPK/ULK1 pathway in differentiated SH-SY5Y cells and dopaminergic neurons in vivo.

Huang Y(1), Liang B(1), Li Z(1), Zhong Y(1), Wang B(1), Zhang B(1), Du J(1), Ye R(1), Xian H(1), Min W(2), Yan X(3), Deng Y(1), Feng Y(1), Bai R(1), Fan B(1), Yang X(4), Huang Z(5).

Author information: (1)NMPA Key Laboratory for Safety Evaluation of Cosmetics, Guangdong Provincial Key Laboratory of Tropical Disease Research, Department of Toxicology, School of Public Health, Southern Medical University, Guangzhou, 510515, People’s Republic of China. (2)School of Environmental Science and Engineering, Shandong University, Qingdao, 266237, People’s Republic of China. (3)Institute of Environmental Research at Greater Bay Area, Key Laboratory for Water Quality and Conservation of the Pearl River Delta, Ministry of Education, Guangzhou University, Guangzhou, 510006, People’s Republic of China. (4)NMPA Key Laboratory for Safety Evaluation of Cosmetics, Food Safety and Health Research Center, School of Public Health, Southern Medical University, Guangzhou, 510515, People’s Republic of China. (5)NMPA Key Laboratory for Safety Evaluation of Cosmetics, Guangdong Provincial Key Laboratory of Tropical Disease Research, Department of Toxicology, School of Public Health, Southern Medical University, Guangzhou, 510515, People’s Republic of China. huangzhenlie858252@smu.edu.cn.

BACKGROUND: Microplastics and nanoplastics (MNPs) are emerging environmental contaminants detected in human samples, and have raised concerns regarding their potential risks to human health, particularly neurotoxicity. This study aimed to investigate the deleterious effects of polystyrene nanoplastics (PS-NPs, 50 nm) and understand their mechanisms in inducing Parkinson’s disease (PD)-like neurodegeneration, along with exploring preventive strategies.

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