Case report of delayed seroprotection rather than non-response after primary three-dose hepatitis B vaccination.

Vaccine 2020

["Koc, \u00d6zg\u00fcr M", "Damoiseaux, Jan", "van Loo, Inge H M", "Masquillier, Heloise I L", "Oude Lashof, Astrid M L"]

Abstract

We describe a delayed hepatitis B seroprotection 12 weeks after the primary vaccination schedule in a 57-year-old male with smoldering multiple myeloma. Based on undetectable anti-HBs antibodies 6 weeks after the third vaccination, the index person was previously considered to be a hepatitis B vaccine non-responder. Because hepatitis B vaccination started in the 1980s, many hepatitis B vaccine non-responders have received a revaccination regimen. If more cases of genuine delayed hepatitis B seroprotection surface in patients with hematologic malignancies, delayed seroprotection should be considered before the commencement of hepatitis B revaccination.

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