TREM2 Ectodomain Variant — AlphaFold Base

MEPLRPPWHLLLLCLCLLSLLPSGFSTEETVSTGPLEKRQLLTRGNIFSQTENLRQGEQDSFPIYVYSLGLGGSPSVQCNVRQGLSWTHEFTVTYTDLVPNGGSCSNFSSMRYHRSRRCSVRVYTLSITGITPSLRYHMKQQGKLLVTLPQQAVQDFPLWLQVNFSDKKLLEVPMQGISNTSSVYFVSLHSVVKMADVRGLVWGWMNVTDQSAQIVTFTTQADKPCKFPMYRNNFTSIDFQILVPVGCVSSGKEKEKMLRTVYVDEVMDRGPRDRV

{
  "method": "alphafold",
  "sequence": "MEPLRPPWHLLLLCLCLLSLLPSGFSTEETVSTGPLEKRQLLTRGNIFSQTENLRQGEQDSFPIYVYSLGLGGSPSVQCNVRQGLSWTHEFTVTYTDLVPNGGSCSNFSSMRYHRSRRCSVRVYTLSITGITPSLRYHMKQQGKLLVTLPQQAVQDFPLWLQVNFSDKKLLEVPMQGISNTSSVYFVSLHSVVKMADVRGLVWGWMNVTDQSAQIVTFTTQADKPCKFPMYRNNFTSIDFQILVPVGCVSSGKEKEKMLRTVYVDEVMDRGPRDRV",
  "mutations": [],
  "uniprot_id": "Q9NZC2",
  "plddt_score": 0.89,
  "binding_affinity": {
    "kd_nm": 850,
    "target": "Aβ oligomers"
  },
  "design_rationale": "Wild-type ectodomain structure as baseline for optimization",
  "predicted_stability": 0.72
}