• Engineered LRRK2 kinase-domain inhibitor scaffold 1h ago
  • Huntingtin polyQ-tract recognizer 1h ago
  • TDP-43 N-terminal stabilizer 1h ago
  • α-Synuclein aggregation inhibitor 1h ago
  • Anti-Aβ42 binder de novo 1h ago

Binder selective for polyQ tracts >35 repeats; targets mutant HTT for selective degradation via PROTAC linker.

Details

sequence
MQQQQQQQQQQQQQQQRYRELGFCGSFNCRSKRKLFCANCGNRH
method
esm-fold
target_function
binder
target_id
P42858
target_family
polyQ
fold
alpha
domain
huntingtons
af2_confidence
75.2
Raw fields (1)
metadata
{}

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