Version history

1 version on record. Newest first; the live version sits at the top with a live indicator.

Live

4/4/2026, 5:16:58 AM

Content snapshot

{
  "sequence": "MEPLRGLLVLAGLAFWHLRGGWAPGALLLWSLGPSLGRAHSGPASCQLLACSLSTLAALCASCVLVVVSTALLFLLLLSLAALQLWQRGVAPSRQGPA",
  "target_protein": "Aβ oligomers",
  "score": 0.75,
  "method": "rosetta_relax",
  "metadata": {
    "method": "rosetta_relax",
    "sequence": "MEPLRGLLVLAGLAFWHLRGGWAPGALLLWSLGPSLGRAHSGPASCQLLACSLSTLAALCASCVLVVVSTALLFLLLLSLAALQLWQRGVAPSRQGPA",
    "mutations": [
      "T96S",
      "K186R",
      "A192V"
    ],
    "uniprot_id": "Q9NZC2",
    "plddt_score": 0.89,
    "delta_G_kcal": -2.3,
    "rosetta_energy": -45.2,
    "binding_affinity": {
      "kd_nm": 780,
      "target": "Aβ oligomers"
    },
    "design_rationale": "Rosetta-guided mutations to improve thermostability without disrupting binding interface",
    "structure_pdb_url": null,
    "predicted_stability": 0.91
  }
}