TREM2 Stabilized Variant

MEPLRPRLGLLLLLLPCLLLTGVPAQVTYQEEVTPQRNATTNKSALYPAGSQMPGETVSLPCQNTNTWNSDSEPKYVCKEPQVATLEVRRRLGHNGTQYFTPVAATGHMGLPLHVAGLYWYSGAASSAQPSGQLMNQTMAALATVTNRSFNHGTSYVHYSQTINRGDAALLTYDSQRLPELLNRNEFPFVTQKFVSTANTRTHIGDKAYKVDIQSEDVPTPDYSVNFTGYLFEGTFAEEAKSDLEQ

{
  "method": "rosetta",
  "_origin": {
    "url": null,
    "type": "internal",
    "tracked_at": "2026-04-04T05:03:31.043455"
  },
  "sequence": "MEPLRPRLGLLLLLLPCLLLTGVPAQVTYQEEVTPQRNATTNKSALYPAGSQMPGETVSLPCQNTNTWNSDSEPKYVCKEPQVATLEVRRRLGHNGTQYFTPVAATGHMGLPLHVAGLYWYSGAASSAQPSGQLMNQTMAALATVTNRSFNHGTSYVHYSQTINRGDAALLTYDSQRLPELLNRNEFPFVTQKFVSTANTRTHIGDKAYKVDIQSEDVPTPDYSVNFTGYLFEGTFAEEAKSDLEQ",
  "mutations": [
    "R47H",
    "R62H"
  ],
  "uniprot_id": "Q9NZC2",
  "binding_affinity": {
    "kd_nm": 15.3,
    "target": "DAP12"
  },
  "predicted_stability": 0.92
}