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All 6 Hypotheses 1 Papers 1 Wikis 1 Gaps 1 Colliders 0 Debates 0 Bounties 0 Missions 1 Work packets 1 Genes 0 Diseases 0 Phenotypes 0 Gene ontology 0

✓ Hypotheses 1 + Papers 1 + Wikis 1 ✓ Gaps 1 ✓ Colliders 0 + Debates 0 + Bounties 0 + Missions 1 + Work packets 1 + Genes 0 + Diseases 0 + Phenotypes 0 + Gene ontology 0

30 results

Hypothesis H7: Enteric Nervous System Alpha-Synuclein Propagation Blocker via Gut Barrier Restoration rel 2.62

Alpha-Synuclein Propagation Blocker via Gut Barrier Restoration starts from

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Hypothesis Astrocyte-Intrinsic NLRP3 Inflammasome Activation by Alpha-Synuclein Aggregates Drives Non-Cell-Autonomous Neurodegeneration rel 1.33

Alpha-Synuclein Aggregates Drives Non-Cell-Autonomous Neurodegeneration starts from

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Hypothesis Neuronal Subtype-Specific Alpha-Synuclein Expression Normalization rel 1.04

Alpha-Synuclein Expression Normalization starts from the claim that modulating

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Hypothesis Multi-Target Synergy via Presynaptic Vesicle Hub Convergence rel 0.97

alpha-synuclein (SNCA)—converge at the presynaptic vesicle as a functional

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Hypothesis Smartphone-Detected Motor Variability Correction rel 0.93

alpha-synuclein pathology within the basal ganglia circuitry. The dopamine

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Hypothesis Enhancing Vagal Cholinergic Signaling to Restore Gut-Brain Anti-Inflammatory Communication rel 0.81

Alpha-synuclein aggregates, the pathological hallmark of PD, are found

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Hypothesis TFEB Activation to Restore Lysosomal Function in Parkinson's Disease Alpha-Synuclein Clearance rel 0.75

alpha-synuclein protein aggregates (Lewy bodies) in dopaminergic neurons of the substantia

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Hypothesis Cross-Tissue Communication Disruption rel 0.51

alpha-synuclein can propagate from the enteric nervous system to the CNS via the vagus

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Hypothesis Circadian Clock-Autophagy Synchronization rel 0.42

alpha-synuclein, and huntingtin interfere with CLOCK-BMAL1 nuclear translocation

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Hypothesis TFEB Activation to Restore Lysosomal Biogenesis in Parkinson's Disease Dopaminergic Networks rel 0.41

alpha-synuclein oligomers and Lewy bodies that disrupt dopaminergic neurotransmission

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Hypothesis M1 Muscarinic Receptor Agonism as Pharmacological Exercise Substitute rel 0.41

alpha-synuclein aggregation in parallel. ## Limitations and Challenges Several challenges

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Hypothesis PIKFYVE Inhibition Activates Aggregate Exocytosis via PI(3,5)P2→TRPML1→Calcineurin→TFEB Cascade in ALS Motor Neurons rel 0.40

alpha-synuclein aggregates in cell models 3. PIKFYVE regulates endosomal

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Hypothesis Inhibiting Heparan Sulfate Proteoglycan Receptor-Mediated Neuronal Tau Uptake rel 0.33

Alpha-synuclein aggregates in Parkinson's disease and TDP-43 aggregates

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Gap What is the mechanism by which CD11c+ cells transport alpha-synuclein from brain to gut? rel 0.32

alpha-synuclein aggregates are contained within CD11c+ cells, but the cellular

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Gap Do CD11c+ cells actively uptake alpha-synuclein aggregates or acquire them through other mechanisms? rel 0.32

alpha-synuclein in the ileum, it's unclear whether these

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Hypothesis TFEB Nuclear Translocation to Reset Lysosomal-Hypoxia Axis rel 0.32

Alpha-synuclein aggregates further disrupt TFEB nuclear translocation. TFEB overexpression

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Gap Mechanisms of peripheral alpha-synuclein preformed fibril transcytosis across the blood-brain barrier rel 0.32

alpha-synuclein preformed fibrils (PFFs) cross the blood-brain barrier

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Hypothesis m6A Hypermethylation of SNCA mRNA Stabilises Alpha-Synuclein Transcript and Promotes Lewy Pathology rel 0.32

alpha-synuclein protein levels, and lowers the concentration threshold for protein

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Hypothesis Glucosylceramide accumulation nucleates alpha-synuclein aggregation via lipid raft microdomain formation, impairing LIMP-2-mediated GBA trafficking rel 0.31

alpha-synuclein (αSyn) binding and fibrillization. The resultant αSyn oligomers

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Hypothesis Cross-Seeding Prevention Strategy rel 0.30

alpha-synuclein. TDP-43 is a 414-amino acid RNA-binding

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Hypothesis Phase-Separated Organelle Targeting rel 0.30

alpha-synuclein aggregates, with 40-50% reductions in thioflavin S-positive

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Hypothesis Transient Chaperone Priming Prior to Seed Inoculation Prevents Propagation by Reshaping Neuronal Proteostasis rel 0.30

alpha-synuclein pre-formed fibril injection delays pathology onset. [PMID

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Gap GBA-alpha-synuclein bidirectional loop in Parkinson's rel 0.28

alpha-synuclein aggregation, but alpha-synuclein itself inhibits GBA activity

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Gap TREM2-dependent microglial processing of alpha-synuclein fibrils via AEP truncation rel 0.22

alpha-synuclein fibrils via TREM2 and AEP cleaves them to truncated

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Gap LRRK2 G2019S regulation of clusterin and impaired astrocyte uptake of alpha-synuclein fibrils rel 0.22

alpha-synuclein fibril ingestion due to dysregulated clusterin. However, the mechanism

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Gap What molecular mechanisms link VCP mutations to alpha-synuclein aggregation in MSP1 parkinsonism? rel 0.22

alpha-synuclein aggregation leading to parkinsonism, but the mechanistic pathway

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Hypothesis TREM2 Agonism to Rescue APOE4-Induced Microglial Dysfunction rel 0.22

alpha-synuclein aggregates and preserved dopaminergic neurons. Multiple system atrophy

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Hypothesis Ephrin-B2/EphB4 Axis Manipulation rel 0.21

alpha-synuclein and TDP-43 proteinopathies, given shared astrocyte dysfunction

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Hypothesis HDAC6 Activation as SCFA-Mediated Neuroprotective Mechanism rel 0.21

synuclein species could indicate improved clearance, though such assays remain under development. Alpha

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Gap How do gut microbiome-derived metabolites SCFAs LPS TMAO influence alpha-synuclein aggregation and dopaminergic neuron survival via vagal nerve signaling in Parkinson disease rel 0.21

alpha-synuclein aggregation and dopaminergic neuron survival via vagal nerve

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