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All 7 Hypotheses 1 Papers 1 Wikis 1 Gaps 1 Colliders 0 Debates 1 Bounties 0 Missions 1 Work packets 1 Genes 0 Diseases 0 Phenotypes 0 Gene ontology 0

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30 results

Hypothesis APOE-Dependent Autophagy Restoration rel 6.50

Autophagy Axis The APOE4 allele disrupts autophagy at three critical

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Hypothesis Circadian-Synchronized Proteostasis Enhancement rel 5.20

autophagy capacity. By administering selective autophagy enhancers precisely during the circadian

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Hypothesis Transcriptional Autophagy-Lysosome Coupling rel 5.00

Autophagy-Lysosome Coupling via FOXO1-TFEB Coordination** **Overview: The Autophagy

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Hypothesis Autophagy-Senescence Axis Therapeutic Window rel 4.20

Autophagy-Related 7):** - ATG7 is an essential autophagy gene required

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Hypothesis LRP1-Autophagy BBB Permeabilization for Antibody Transport rel 3.90

autophagy pathway in BMECs. [PMID:31504123]. 2. Pharmacological autophagy induction

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Hypothesis Circadian Clock-Autophagy Synchronization rel 3.80

autophagy-related genes, creating a temporal hierarchy where autophagy induction

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Hypothesis Autophagosome Maturation Checkpoint Control rel 3.30

autophagy initiation through mTOR-independent mechanisms, paradoxically worsening the cellular

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Hypothesis VCP-Mediated Autophagy Enhancement rel 3.20

Autophagy Enhancement starts from the claim that modulating VCP within

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Hypothesis Sequential TRPML1 Activation Following Autophagy Priming rel 3.20

Autophagy Priming: Establishing a Responsive Lysosomal Environment Autophagy priming refers

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Hypothesis TFEB-Independent Autophagy Bypass rel 3.00

Autophagy Bypass starts from the claim that modulating ULK1 within

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Hypothesis ER Stress Reduction as Adjunctive Therapy to Support Autophagy rel 2.80

autophagy initiation. Autophagy, the lysosome-mediated degradation of cellular components

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Hypothesis Gamma Oscillation Entrainment Enhances lncRNA-9969-Mediated Autophagy Through PV Interneuron-Specific ceRNA Networks rel 2.80

autophagy suppression by binding to 3'-UTR regions of autophagy

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Hypothesis Alpha-Beta Oscillation Coupling Enhances lncRNA-9969-Mediated Autophagy Through SST Interneuron-Specific ceRNA Networks rel 2.60

Autophagy Through SST Interneuron-Specific ceRNA Networks starts from the claim

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Hypothesis Alpha-Theta Oscillation Modulation Enhances lncRNA-9969-Mediated Autophagy Through SST Interneuron-Specific ceRNA Networks rel 2.40

Autophagy Through SST Interneuron-Specific ceRNA Networks starts from the claim

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Hypothesis Closed-loop tACS targeting entorhinal cortex layer II SST interneurons to activate AMPK-autophagy flux and degrade intracellular tau before exosomal packaging in Alzheimer's disease rel 2.30

autophagy machinery specifically targets hyperphosphorylated tau species through selective autophagy

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Hypothesis TFEB Nuclear Translocation to Reset Lysosomal-Hypoxia Axis rel 2.20

autophagy initiation. - **TBK1** (TANK-binding kinase 1): Phosphorylates autophagy receptors

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Hypothesis hnRNPA2B1-Mediated Structural Remodeling Controls lncRNA-0021 Accessibility for miR-6361 Sequestration rel 2.20

autophagy pathways critical for Alzheimer's disease pathogenesis. hnRNPA2B1, a 37 kDa RNA-binding

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Hypothesis H2: Impaired Autophagy Receptor Recruitment Traps G3BP1 Granules rel 2.10

autophagy. TBK1 phosphorylates key autophagy receptors including p62/SQSTM1 (sequestosome 1) at Ser403

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Hypothesis Autophagy-Lysosomal Degradation of IBA1 in Stressed Microglia rel 2.00

autophagy in astrocytes. [PMID:25715680]. 2. Microglia upregulate autophagy in neurodegeneration

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Hypothesis REDD1-mTOR Axis as the Master Regulator — Preservation Over Chelation rel 2.00

autophagy initiation machinery, including ULK1 at Ser757, ATG13 at Ser355

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Hypothesis TBK1-OPTN-NDP52 Phospho-Cascade Coordinates Multi-Organelle Autophagy rel 1.90

Autophagy starts from the claim that modulating TBK1, OPTN (TBC1D7

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Hypothesis VCP/p97 ATPase mutations impair extraction of ubiquitinated autophagy substrates, causing proteasome-autophagy flux obstruction rel 1.80

autophagy substrates, causing proteasome-autophagy flux obstruction starts from the claim

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Hypothesis VPS34 Complex I Subunit Heterogeneity Dictates Organelle-Specific vs. Bulk Autophagy rel 1.70

Autophagy starts from the claim that modulating PIK3C3/VPS34, ATG14L, UVRAG

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Hypothesis C9orf72 DPRs Impair Autophagy Receptor Docking on Stress Granules rel 1.70

autophagy receptor function through steric occlusion of critical ubiquitin-binding

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Hypothesis H7: mTOR Hyperactivity Blocks Autophagy, Permitting Tau Seeding rel 1.60

autophagy in response to metabolic demands. In cortical layer II neurons

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Hypothesis p21^Cip1 Phospho-State as Autophagy Responsiveness Predictor rel 1.60

autophagy-mediated survival. This hypothesis proposes that distinct phosphorylation states

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Hypothesis AMPK Activation to Restore Autophagy and Clear α-Synuclein Aggregates rel 1.50

AUTOPHAGY RESTORATION THERAPY: αSyn aggregates overwhelm the autophagy-lysosome system

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Hypothesis GDF15-GFRAL Axis as Systemic Autophagy-Senescence Integrator rel 1.50

Autophagy-Senescence Integrator starts from the claim that modulating GDF15

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Hypothesis Autophagic Flux Enhancement Synergizes With Chaperones to Clear High-Molecular-Weight Tau Seeds rel 1.50

autophagy receptor that bridges ubiquitinated protein aggregates to the autophagy

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Hypothesis P2RY12-mediated autophagy inhibition in cerebral VSMCs impairs CAA clearance rel 1.50

autophagy through phosphorylation of UNC-51-like autophagy activating kinase

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