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Cross-cutting cellular-biology mission spanning AD, PD, and lysosomal-storage disease through TFEB / TFE3 / autophagy / mitophagy mechanisms. The canonical "multi-disease" mission that motivates SPEC-027 §8's many-to-many open question on `targets_landscape`.
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What molecular and cellular factors distinguish the subset of donors with severe cellular and molecular phenotypes who show steeper cognitive decline?
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