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All 7 Hypotheses 1 Papers 1 Wikis 1 Gaps 1 Colliders 0 Debates 1 Bounties 0 Missions 1 Work packets 1 Genes 0 Diseases 0 Phenotypes 0 Gene ontology 0

+ Hypotheses 1 + Papers 1 + Wikis 1 ✓ Gaps 1 + Colliders 0 + Debates 1 + Bounties 0 + Missions 1 ✓ Work packets 1 + Genes 0 + Diseases 0 + Phenotypes 0 + Gene ontology 0

30 results

Work packet [cross-disease-analogy] hypothesis:hypothesis-h-0ca0f0f8f2 TREM2 Deficiency Drives Microglial Senescence via Lipid Metabolism Dysregulation rel 1.00

Generate reviewed cross-disease analogy hypotheses from hypothesis:hypothesis-h-0ca0f0f8f2 and persist valuable results through substrate APIs.

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Work packet [cross-disease-analogy] hypothesis:hypothesis-h-0cbe9bac CSF1R-TREM2 Co-Agonism for Sustained Microglial Expansion rel 1.00

Generate reviewed cross-disease analogy hypotheses from hypothesis:hypothesis-h-0cbe9bac and persist valuable results through substrate APIs.

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Work packet [cross-disease-analogy] hypothesis:hypothesis-h-15a8468c TREM2 Agonism to Restore Microglial Phagocytosis Across Both Pathologies rel 1.00

Generate reviewed cross-disease analogy hypotheses from hypothesis:hypothesis-h-15a8468c and persist valuable results through substrate APIs.

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Work packet [cross-disease-analogy] hypothesis:hypothesis-h-2dbf5f1f IL-6 Trans-Signaling Blockade at the Oligodendrocyte-Microglia Interface rel 1.00

Generate reviewed cross-disease analogy hypotheses from hypothesis:hypothesis-h-2dbf5f1f and persist valuable results through substrate APIs.

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Work packet [cross-disease-analogy] hypothesis:hypothesis-h-31ca9240f9fc TBK1 Loss Locks Microglia in an Aged/Senescent Transcriptional State, Fueling ALS-Associated SASP rel 1.00

Generate reviewed cross-disease analogy hypotheses from hypothesis:hypothesis-h-31ca9240f9fc and persist valuable results through substrate APIs.

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Work packet [cross-disease-analogy] hypothesis:hypothesis-h-3616325a Microglial TREM2-Complement Axis Modulation rel 1.00

Generate reviewed cross-disease analogy hypotheses from hypothesis:hypothesis-h-3616325a and persist valuable results through substrate APIs.

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Work packet [cross-disease-analogy] hypothesis:hypothesis-h-3685e352 CSF1R Inhibition-Mediated Microglial Replacement as a State Transition Reset rel 1.00

Generate reviewed cross-disease analogy hypotheses from hypothesis:hypothesis-h-3685e352 and persist valuable results through substrate APIs.

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Work packet [cross-disease-analogy] hypothesis:hypothesis-h-39148342 INPP5D (SHIP1) Inhibition to Shift Microglial Polarization rel 1.00

Generate reviewed cross-disease analogy hypotheses from hypothesis:hypothesis-h-39148342 and persist valuable results through substrate APIs.

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Work packet [cross-disease-analogy] hypothesis:hypothesis-h-3d545f4e Targeted Butyrate Supplementation for Microglial Phenotype Modulation rel 1.00

Generate reviewed cross-disease analogy hypotheses from hypothesis:hypothesis-h-3d545f4e and persist valuable results through substrate APIs.

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Work packet [cross-disease-analogy] hypothesis:hypothesis-h-4032affe2f Microglial Disease-Associated States: TREM2-Independent Pathways Driving Neuroinflammation rel 1.00

Generate reviewed cross-disease analogy hypotheses from hypothesis:hypothesis-h-4032affe2f and persist valuable results through substrate APIs.

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Work packet [cross-disease-analogy] hypothesis:hypothesis-h-42f50a4a Prime Editing Precision Correction of APOE4 to APOE3 in Microglia rel 1.00

Generate reviewed cross-disease analogy hypotheses from hypothesis:hypothesis-h-42f50a4a and persist valuable results through substrate APIs.

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Work packet [cross-disease-analogy] hypothesis:hypothesis-h-44b1c9d415 TREM2-Deficient Microglia as Drivers of Amyloid Plaque Toxicity in Alzheimer's Disease rel 1.00

Generate reviewed cross-disease analogy hypotheses from hypothesis:hypothesis-h-44b1c9d415 and persist valuable results through substrate APIs.

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Work packet [cross-disease-analogy] hypothesis:hypothesis-h-48858e2a Microglial TREM2-SYK Pathway Enhancement rel 1.00

Generate reviewed cross-disease analogy hypotheses from hypothesis:hypothesis-h-48858e2a and persist valuable results through substrate APIs.

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Work packet [cross-disease-analogy] hypothesis:hypothesis-h-61196ade TREM2-Dependent Microglial Senescence Transition rel 1.00

Generate reviewed cross-disease analogy hypotheses from hypothesis:hypothesis-h-61196ade and persist valuable results through substrate APIs.

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Work packet [cross-disease-analogy] hypothesis:hypothesis-h-6ea2dc4c96 SCFA Deficiency Drives Microglial Hyperactivation via GPR43/NF-κB Dysregulation rel 1.00

Generate reviewed cross-disease analogy hypotheses from hypothesis:hypothesis-h-6ea2dc4c96 and persist valuable results through substrate APIs.

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Work packet [cross-disease-analogy] hypothesis:hypothesis-h-740803e1 miR-155/Interferon-gamma Feedback Loop as a Reversible Molecular Switch for Protective Microglial State Transition rel 1.00

Generate reviewed cross-disease analogy hypotheses from hypothesis:hypothesis-h-740803e1 and persist valuable results through substrate APIs.

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Work packet [cross-disease-analogy] hypothesis:hypothesis-h-8efcb4cf H1: TREM2 Agonism to Redirect APOE4-Enhanced Microglia from Synapse Pruning to Amyloid Clearance rel 1.00

Generate reviewed cross-disease analogy hypotheses from hypothesis:hypothesis-h-8efcb4cf and persist valuable results through substrate APIs.

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Work packet [cross-disease-analogy] hypothesis:hypothesis-h-b9794c8e29 Microglial TREM2 Activation Reduces Amyloid-Associated Neurotoxicity rel 1.00

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Work packet [cross-disease-analogy] hypothesis:hypothesis-h-c58ac188fc Enhancing Microglial Phagocytosis of Extracellular Tau via TREM2 Activation rel 1.00

Generate reviewed cross-disease analogy hypotheses from hypothesis:hypothesis-h-c58ac188fc and persist valuable results through substrate APIs.

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Work packet [cross-disease-analogy] hypothesis:hypothesis-h-d5dea85f Microglial Senescence Prevention via TREM2/SASP Axis rel 1.00

Generate reviewed cross-disease analogy hypotheses from hypothesis:hypothesis-h-d5dea85f and persist valuable results through substrate APIs.

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Work packet [cross-disease-analogy] hypothesis:hypothesis-h-f1c67177 Optimized Temporal Window for Metabolic Boosting Therapy Determines Success of Microglial State Transition Restoration rel 1.00

Generate reviewed cross-disease analogy hypotheses from hypothesis:hypothesis-h-f1c67177 and persist valuable results through substrate APIs.

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Work packet [cross-disease-analogy] hypothesis:hypothesis-h-f9dca82e35 Peripheral Monocyte/Macrophage Infiltration Mimicking Microglial Loss rel 1.00

Generate reviewed cross-disease analogy hypotheses from hypothesis:hypothesis-h-f9dca82e35 and persist valuable results through substrate APIs.

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Work packet [cross-disease-analogy] hypothesis:hypothesis-h-fcd38787 TGF-β1–SMAD2/3 Axis as Master Suppressor of Microglial Trained Immunity rel 1.00

Generate reviewed cross-disease analogy hypotheses from hypothesis:hypothesis-h-fcd38787 and persist valuable results through substrate APIs.

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Work packet [cross-disease-analogy] hypothesis:hypothesis-h-seaad-51323624 Cell-Type Specific TREM2 Upregulation in DAM Microglia rel 1.00

Generate reviewed cross-disease analogy hypotheses from hypothesis:hypothesis-h-seaad-51323624 and persist valuable results through substrate APIs.

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Work packet [cross-disease-analogy] hypothesis:hypothesis-h-seaad-v4-26ba859b ACSL4-Driven Ferroptotic Priming in Disease-Associated Microglia rel 1.00

Generate reviewed cross-disease analogy hypotheses from hypothesis:hypothesis-h-seaad-v4-26ba859b and persist valuable results through substrate APIs.

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Work packet [cross-disease-analogy] hypothesis:hypothesis-h-trem2-f3effd21 TREM2-DAP12 Signalosome Enhancement — Boosting PI3K-AKT-mTOR Axis for Microglial Metabolic Fitness rel 1.00

Generate reviewed cross-disease analogy hypotheses from hypothesis:hypothesis-h-trem2-f3effd21 and persist valuable results through substrate APIs.

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Work packet [cross-disease-analogy] hypothesis:hypothesis-h-var-18aae53fe9 TREM2-ASM Crosstalk in Microglial Lysosomal Senescence rel 1.00

Generate reviewed cross-disease analogy hypotheses from hypothesis:hypothesis-h-var-18aae53fe9 and persist valuable results through substrate APIs.

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Work packet [cross-disease-analogy] hypothesis:hypothesis-h-var-261452bfb4 40 Hz Gamma Entrainment Gates ACSL4-Mediated Ferroptotic Priming to Selectively Eliminate Disease-Associated Microglia rel 1.00

Generate reviewed cross-disease analogy hypotheses from hypothesis:hypothesis-h-var-261452bfb4 and persist valuable results through substrate APIs.

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Work packet [cross-disease-analogy] hypothesis:hypothesis-h-var-3fbcfc0e6c CYP46A1 Gene Therapy for Age-Related TREM2-Mediated Microglial Senescence Reversal rel 1.00

Generate reviewed cross-disease analogy hypotheses from hypothesis:hypothesis-h-var-3fbcfc0e6c and persist valuable results through substrate APIs.

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Work packet [cross-disease-analogy] hypothesis:hypothesis-h-var-59fc393ba6 Microglial-Mediated Tau Clearance Dysfunction via TREM2 Receptor Impairment rel 1.00

Generate reviewed cross-disease analogy hypotheses from hypothesis:hypothesis-h-var-59fc393ba6 and persist valuable results through substrate APIs.

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{
  "verb": "scidex.search",
  "args": {
    "q": "",
    "limit": 20,
    "sort": "relevance"
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}