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All 8 Hypotheses 1 Papers 1 Wikis 1 Gaps 1 Colliders 1 Debates 1 Bounties 0 Missions 1 Work packets 1 Genes 0 Diseases 0 Phenotypes 0 Gene ontology 0

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30 results

Wiki Validated Hypothesis: Inhibiting Heparan Sulfate Proteoglycan Receptor-Mediated Neuronal Tau Uptake rel 8.10

tau pathology, including tau immunotherapy, microtubule-stabilizing agents, and tau

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Wiki Validated Hypothesis: Microglial-Mediated Tau Clearance Dysfunction via TREM2 Signaling rel 7.10

tau aggregates—composed predominantly of MAPT-encoded tau protein in its pathological

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Wiki Validated Hypothesis: LRP1-Dependent Tau Uptake Disruption rel 7.10

tau species, wherein diseased neurons release tau aggregates that are subsequently

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Hypothesis Inhibiting Heparan Sulfate Proteoglycan Receptor-Mediated Neuronal Tau Uptake rel 7.00

tau pathology, including tau immunotherapy, microtubule-stabilizing agents, and tau

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Hypothesis LRP1-Dependent Tau Uptake Disruption rel 6.50

tau species, wherein diseased neurons release tau aggregates that are subsequently

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Hypothesis Synaptic Vesicle Tau Capture Inhibition rel 6.40

tau propagation. Recent studies have identified tau species within synaptic

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Wiki Validated Hypothesis: Extracellular Vesicle Biogenesis Modulation rel 6.10

tau species between neurons, enabling the propagation of tau aggregates

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Hypothesis Excitatory Neuron Synaptic Dysfunction and Mitochondrial Stress via MAPT (tau) rel 6.00

tau's toxic effects on cellular energetics. Tau pathology disrupts

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Hypothesis Extracellular Vesicle Biogenesis Modulation rel 5.70

tau species between neurons, enabling the propagation of tau aggregates

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Hypothesis TREM2-mediated microglial tau clearance enhancement rel 5.70

tau transgenic mouse model resulted in increased tau pathology, enhanced

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Hypothesis GPC4/HSPGs Collaborate with ApoE Isoforms to Dictate Tau Conformational Strain Uptake Efficiency rel 5.70

tau species. Upon binding, the GPC4-APOE-tau complex undergoes

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Hypothesis Conformational-Selective Blocking of Tau Uptake Reveals Therapeutic Window in Neuronal Re-entry rel 5.00

tau pathology. The conformational selectivity arises from pathological tau's adoption

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Wiki Validated Hypothesis: TREM2-Mediated Microglial Dysfunction Disrupts Perivascular Tau Clearance rel 4.40

tau aggregate degradation. The secondary mechanism involves perivascular tau accumulation

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Hypothesis CDK5 Inhibition at Presynaptic Terminals Prevents Activity-Dependent Tau Release and Transsynaptic Propagation rel 4.30

tau levels and a corresponding 35% decrease in tau pathology

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Wiki Validated Hypothesis: Glymphatic-Mediated Tau Clearance Dysfunction rel 4.30

tau transgenic mice accelerates cognitive decline and increases insoluble tau

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Hypothesis DAPK1 Inhibition as Dual-Mechanism Neuroprotection Against Tau-Induced Destabilization rel 4.20

tau transgenic mice reduces tau phosphorylation at pathogenic sites, preserves

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Hypothesis DLK MAPK Pathway Inhibition to Block Tau-Induced Neurotoxicity Without Directly Targeting Tau rel 4.20

Tau-Induced Neurotoxicity Without Directly Targeting Tau starts from the claim

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Wiki Validated Hypothesis: Closed-loop tACS targeting EC-II PV interneurons to suppress burst firing and block tau propagation via perforant path in AD rel 4.20

tau pathology in 5XFAD and tau P301S mice. Identifier 31076275. This

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Hypothesis HSP90-Tau Disaggregation Complex Enhancement rel 4.00

tau levels and improved cognitive function in tau transgenic mice

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Hypothesis Tau Propagation Blockade via Synaptic Ephrin-B2/ephrin-B Signaling Modulation rel 3.80

tau propagation rests on several converging observations. First, tau pathology

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Hypothesis H7: mTOR Hyperactivity Blocks Autophagy, Permitting Tau Seeding rel 3.80

tau-tau interactions and thioflavin-S-positive tau inclusions. Quantitative

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Hypothesis Autophagic Flux Enhancement Synergizes With Chaperones to Clear High-Molecular-Weight Tau Seeds rel 3.80

tau pathology, p62 accumulates around tau inclusions and facilitates their

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Wiki ALZHEIMER rel 3.70

tau_hyp["Tau hyperphosphorylation"] tau_hyp -->|"aggregates into"| NFT["NFTs

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Wiki Validated Hypothesis: Closed-loop tACS targeting EC-II parvalbumin interneurons to restore gamma rhythmogenesis and block tau AIS disruption in AD rel 3.70

tau mouse model, tau pathology was sufficient to produce excitatory

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Hypothesis Enhancing Microglial Phagocytosis of Extracellular Tau via TREM2 Activation rel 3.50

tau-positive vesicles and lysosomal markers. The P301S tau transgenic

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Hypothesis TREM2-Dependent Microglial Phagocytosis Acts as a Strain Selection Filter rel 3.40

tau pathology, with reduced plaque-associated microgliosis and enhanced tau

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Hypothesis Seed Conformational Heterogeneity Explains Variable Chaperone Susceptibility—Strain-Specific Targeting Required rel 3.40

tau conformers within the disease context of protein folding can redirect

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Wiki Validated Hypothesis: Beta-frequency entrainment therapy targeting PV interneuron-astrocyte coupling for tau clearance rel 3.40

tau tracers (18F-flortaucipir) to assess regional tau burden changes

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Wiki Validated Hypothesis: Closed-loop focused ultrasound targeting EC-II PV interneurons to restore theta-gamma coupling and prevent tau seeding in AD rel 3.20

tau pathology in 5XFAD and tau P301S mice. Identifier 31076275. This

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Hypothesis NLRP3 Inflammasome Blockade as Upstream Intervention to Prevent SASP Amplification rel 3.10

tau hyperphosphorylation, aggregation, and intercellular propagation, while pathological tau species

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