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30 results

Paper TDP-43 Oligomerization and Phase Separation Properties Are Necessary for Autoregulation. rel 2.27

TDP-43 protein homeostasis and dysfunction, in particular TDP-43

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Paper Tar DNA binding protein-43 (TDP-43) associates with stress granules: analysis of cultured cells and pathological brain tissue. rel 2.06

TDP-43 increased TDP-43 inclusion formation in response to stressful

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Paper ALS-linked TDP-43 mutations produce aberrant RNA splicing and adult-onset motor neuron disease without aggregation or loss of nuclear TDP-43. rel 2.04

TDP-43(Q331K) and TDP-43(M337V)), but not wild

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Paper Optineurin knock-out forms TDP-43 aggregates to regulate TDP-43 protein levels despite autophagic up-regulation and aberrant TDP-43 expression. rel 2.03

TDP-43-transgenic (TDP-43-tg) mice resulted in motor

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Paper The Pathobiology of TDP-43 C-Terminal Fragments in ALS and FTLD. rel 1.81

TDP-43 CTF cell culture models. Furthermore, TDP-43 CTF expression

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Paper Nuclear import receptors are recruited by FG-nucleoporins to rescue hallmarks of TDP-43 proteinopathy. rel 1.78

TDP-43 fibrils in vitro. Fly models of TDP-43

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Paper Molecular mechanisms and consequences of TDP-43 phosphorylation in neurodegeneration. rel 1.64

TDP-43 phosphorylation on TDP-43 pathology, especially related to TDP

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Paper Heat Shock-induced Phosphorylation of TAR DNA-binding Protein 43 (TDP-43) by MAPK/ERK Kinase Regulates TDP-43 Function. rel 1.61

TDP-43 was not associated with TDP-43 aggregation, and p-T153

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Paper Identification of neuronal RNA targets of TDP-43-containing ribonucleoprotein complexes. rel 1.60

TDP-43 RIP-seq library. TDP-43 RNA targets can be divided

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Paper Opposing roles of p38α-mediated phosphorylation and PRMT1-mediated arginine methylation in driving TDP-43 proteinopathy. rel 1.53

TDP-43. The mechanisms underlying toxic TDP-43 accumulation are not understood

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Paper Opposing roles of p38α-mediated phosphorylation and PRMT1-mediated arginine methylation in driving TDP-43 proteinopathy. rel 1.53

TDP-43. The mechanisms underlying toxic TDP-43 accumulation are not understood

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Paper TDP-43 induces mitochondrial damage and activates the mitochondrial unfolded protein response. rel 1.52

TDP-43 gene have been associated with TDP-43 proteinopathy

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Paper TDP-43 pathology is associated with increased tau burdens and seeding. rel 1.51

TDP-43 pathology TDP-43: AD(LATE-NC-). Accumulating evidence

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Paper The C-terminal TDP-43 fragments have a high aggregation propensity and harm neurons by a dominant-negative mechanism. rel 1.51

TDP-43, consequently reducing the nuclear TDP-43. In addition

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Paper A quantitative cell-based reporter links TDP-43 aggregation and dysfunction to define pathogenic mechanisms. rel 1.50

TDP-43-encephalopathy (LATE). In affected patients, cytoplasmic TDP-43

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Paper Motor neuron TDP-43 proteinopathy in progressive supranuclear palsy and corticobasal degeneration. rel 1.49

TDP-43 pathology was often associated with TDP-43 pathology

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Paper TDP-43 seeding activity in the olfactory mucosa of patients with amyotrophic lateral sclerosis. rel 1.46

TDP-43 (TDP-43_SAA). Plasmatic levels of TDP-43

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Paper TDP-43 proteinopathies and neurodegeneration: insights from Caenorhabditis elegans models. rel 1.46

TDP-43 orthologue TDP-1, serves as a powerful genetic

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Paper TDP-43-regulated cryptic RNAs accumulate in Alzheimer's disease brains. rel 1.45

TDP-43, regardless of TDP-43 subtype classification. Further, cryptic

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Paper Heat-shock chaperone HSPB1 regulates cytoplasmic TDP-43 phase separation and liquid-to-gel transition. rel 1.41

TDP-43 droplets, inhibits TDP-43 assembly into fibrils, and is essential

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Paper Proteomics Analysis of the TDP-43 Interactome in Cellular Models of ALS Pathogenesis. rel 1.40

TDP-43 by comparing TDP-43 interaction partners in three

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Paper RNA aptamer reveals nuclear TDP-43 pathology is an early aggregation event that coincides with STMN-2 cryptic splicing and precedes clinical manifestation in ALS. rel 1.40

TDP-43 APT , to detect TDP-43 pathology and used

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Paper Modelling TDP-43 proteinopathy in Drosophila uncovers shared and neuron-specific targets across ALS and FTD relevant circuits. rel 1.38

TDP-43 and accumulation of cytoplasmic TDP-43 inclusions that

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Paper Therapeutic reduction of ataxin-2 extends lifespan and reduces pathology in TDP-43 mice. rel 1.38

TDP-43-directed therapies for ALS or related TDP-43

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Paper Brain TDP-43 pathology in corticobasal degeneration: Topographical correlation with neuronal loss. rel 1.36

TDP-43 and neuronal loss in CBD, suggesting that TDP

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Paper TDP-43 Cryptic RNAs in Perry Syndrome: Differences across Brain Regions and TDP-43 Proteinopathies. rel 1.33

-43 and TDP-43-regulated cryptic RNAs and protein in the caudate

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Paper Disease-linked TDP-43 hyperphosphorylation suppresses TDP-43 condensation and aggregation. rel 1.32

TDP-43, but suppress accumulation of TDP-43 in membrane

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Paper Disease-linked TDP-43 hyperphosphorylation suppresses TDP-43 condensation and aggregation. rel 1.32

TDP-43, but suppress accumulation of TDP-43 in membrane

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Paper Data-driven neuropathological staging and subtyping of TDP-43 proteinopathies. rel 1.31

TDP-43 accumulation is necessary to better characterize TDP-43

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Paper TDP-43 Phosphorylation: Pathological Modification or Protective Factor Antagonizing TDP-43 Aggregation in Neurodegenerative Diseases? rel 1.31

TDP-43 is normally unphosphorylated. Whether TDP-43 phosphorylation is a pathological

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