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30 results

Wiki ftd-tdp-pathology rel 16.07

TDP-43 TDP-43 is a highly conserved RNA/DNA-binding protein

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Wiki TDP-43 Proteinopathy in Amyotrophic Lateral Sclerosis rel 15.84

TDP-43 Proteinopathy in Amyotrophic Lateral Sclerosis ## Overview TDP-43

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Wiki TDP-43 Proteinopathy rel 13.20

TDP-43 ### Protein Structure and Localization TDP-43 is a 414-amino

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Wiki TDP-43 Protein rel 12.01

TDP-43 --- ## Pathogenesis ### TDP-43 Proteinopathy TDP-43 aggregation follows

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Wiki TDP-43 Pathology in Corticobasal Syndrome rel 11.32

TDP-43 positive | Mixed tau + TDP-43 | ~30% | | TDP-43

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Wiki ftd-tdp43-pathway rel 11.09

TDP-43 Pathology in Frontotemporal Dementia ## Overview **TDP-43 Pathology

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Wiki TDP-43 Co-pathology in Corticobasal Syndrome rel 10.52

TDP-43 positive | Mixed tau + TDP-43 | ~30% | | TDP-43

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Wiki TDP-43 (TAR DNA-Binding Protein 43) - Biomarker rel 9.73

TDP-43 co-pathology [@neumann2006] - TDP-43 pathology is associated

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Wiki Therapeutic Hypothesis: TDP-43 and a-synuclein pathologies in the amygdala... rel 9.66

TDP-43 Proteinopathy TAR DNA-binding protein 43 (TDP-43

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Wiki tdp-43-fus-rna-proteinopathy-comparison rel 8.22

TDP-43/FUS-mediated | TDP-43/FUS-mediated | mHTT-mediated | | **G3BP1 sequestration

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Wiki TARDBP Protein (TDP-43) rel 8.02

TDP-43 causes toxicity - Cytoplasmic TDP-43 disrupts mitochondrial function

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Wiki AD-FTD Tau-TDP-43 Overlap: Mechanism Comparison rel 8.00

TDP-43 (FTLD-TDP) | | **TDP-43 co-pathology rate** | 20-57% | 50% (FTLD

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Wiki Stathmin-2 (SCG10) rel 7.86

TDP-43' unca: title: '- unc13a — Other major TDP-43 cryptic

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Wiki Update TDP-43 protein page with comprehensive content rel 7.75

TDP-43 protein page with comprehensive content TDP-43 (TAR DNA-Binding

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Wiki TAR DNA-Binding Protein 43 (TDP-43) rel 7.17

TDP-43) TAR DNA-Binding Protein 43 (TDP-43) Gene

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Wiki TDP-43 Proteinopathy in ALS rel 6.89

TDP-43 Normal Function TDP-43 is a heterogeneous nuclear

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Hypothesis TDP-43 Cryptic Exon–Targeted ASOs to Restore Hippocampal Gamma Oscillations rel 6.59

TDP-43 involvement. Biomarker strategies, including cerebrospinal fluid TDP-43

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Hypothesis Arginine Methylation Enhancement Therapy rel 6.52

TDP-43. The TDP-43 protein contains multiple arginine-rich

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Wiki TDP-43 PET Ligand Development for Frontotemporal Dementia rel 6.27

TDP-43 PET Ligands Are Needed TDP-43 (TAR DNA-binding

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Wiki Validated Hypothesis: p38α Inhibitor and PRMT1 Activator Combination to Restore Physiological TDP-43 Phosphorylation-Methylation Balance rel 6.19

TDP-43 hyperphosphorylation was established early in TDP-43 biology

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Wiki VCP→TDP-43→ALS/FTD Causal Chain rel 5.95

TDP-43 Pathology ### TDP-43 in Neurodegeneration **TDP-43** (TAR DNA-binding

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Wiki TDP-43 RNA Granule Pathway rel 5.89

TDP-43 RNA Granule Pathway ## Overview The **TDP-43 RNA Granule

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Wiki TARDBP — TAR DNA Binding Protein 43 rel 5.88

TDP-43) TARDBP — TAR DNA Binding Protein 43 TDP-43

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Hypothesis p38α Inhibitor and PRMT1 Activator Combination to Restore Physiological TDP-43 Phosphorylation-Methylation Balance rel 5.57

TDP-43 pathology, and p38α inhibition reduces pathological TDP-43

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Wiki RNA Metabolism Dysregulation in Alzheimer's Disease rel 5.55

TDP-43 incorporation into SGs - Cytoplasmic TDP-43 accumulation ### Processing

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Hypothesis Cross-Seeding Prevention Strategy rel 5.50

TDP-43-Aβ and TDP-43-tau interaction complexes in CSF, with

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Wiki Frontotemporal Dementia (FTD) rel 5.44

TDP-43 Proteinopathy in Frontotemporal Dementia **TDP-43 (TAR DNA-binding

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Wiki TDP-43 Pathology Reversibility in ALS rel 5.41

TDP-43 Biology in Normal Neurons TDP-43 is a nuclear

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Wiki FTLD-TDP Subtypes and Mechanisms rel 5.24

TDP-43 Biology ### Normal TDP-43 Function TDP-43 is a nuclear

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Wiki Molecular Glue for TDP-43 Aggregate Clearance rel 5.12

TDP-43 function[@rascncarcova2024][@kim2024]. ## Target - **Primary Target**: TDP-43

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