MGE Progenitor Transplantation Efficacy Across Disease Models

{
  "papers": [
    {
      "n": 0,
      "doi": "10.1016/j.stem.2023.08.013",
      "value": "most animals seizure-free",
      "method": "continuous video-EEG monitoring",
      "metric": "Seizure suppression rate after MGE interneuron transplant",
      "n_analyzed": null,
      "ci_or_error": null,
      "text_access": "fulltext",
      "n_definition": "animals per treatment group",
      "scope_region": "hippocampus",
      "study_system": "mouse MTLE model, human ESC-derived MGE interneurons",
      "taxonomic_level": "GABAergic interneurons",
      "scope_population": "transplanted MGE interneurons",
      "value_source_sentence": "Single-dose intrahippocampal delivery of the interneurons in a mouse model of chronic MTLE resulted in consistent mesiotemporal seizure suppression, with most animals becoming seizure-free and surviving longer.",
      "experimental_conditions": "single intrahippocampal injection, chronic MTLE"
    },
    {
      "n": 0,
      "doi": "10.1073/pnas.1316488111",
      "value": "mitigation of PV deficits, cognitive deficits, and dopamine dysregulation",
      "method": "in vivo electrophysiology, behavioral testing",
      "metric": "Reversal of hippocampal disinhibition and psychosis-like features after MGE transplant",
      "n_analyzed": null,
      "ci_or_error": null,
      "text_access": "fulltext",
      "n_definition": "animals per group",
      "scope_region": "hippocampus",
      "study_system": "mouse, Ccnd2-null psychosis model",
      "taxonomic_level": "GABAergic interneurons",
      "scope_population": "transplanted MGE interneurons",
      "value_source_sentence": "Transplanting interneuron progenitors derived from the embryonic medial ganglionic eminence into adult hippocampus mitigates these abnormalities.",
      "experimental_conditions": "adult hippocampal transplantation"
    },
    {
      "n": 0,
      "doi": "10.1093/pnasnexus/pgaf077",
      "value": "significant increases in synaptic inhibition",
      "method": "whole-cell voltage-clamp recordings",
      "metric": "Synaptic inhibition restoration after MGE transplant into injured visual cortex",
      "n_analyzed": null,
      "ci_or_error": null,
      "text_access": "fulltext",
      "n_definition": "neurons recorded",
      "scope_region": "visual cortex",
      "study_system": "mouse, traumatic brain injury model",
      "taxonomic_level": "GABAergic interneurons",
      "scope_population": "host L2/3 neurons receiving grafted interneuron input",
      "value_source_sentence": "Following MGE transplantation, we found significant increases in synaptic inhibition in regions of visual cortex containing transplanted MGE progenitors.",
      "experimental_conditions": "MGE transplant 45-60 days post-injury"
    },
    {
      "n": 0,
      "doi": "10.1038/s41536-022-00234-7",
      "value": "silencing graft-derived interneurons increased seizures and impaired location memory",
      "method": "chemogenetic silencing, seizure monitoring, behavioral testing",
      "metric": "Direct functional regulation by grafted interneurons (DREADD silencing reversal)",
      "n_analyzed": null,
      "ci_or_error": null,
      "text_access": "fulltext",
      "n_definition": "animals per group",
      "scope_region": "hippocampus",
      "study_system": "rat, chronic TLE, hPSC-derived MGE interneurons",
      "taxonomic_level": "GABAergic interneurons",
      "scope_population": "grafted MGE-like interneurons",
      "value_source_sentence": "silencing of graft-derived interneurons with a designer drug increased SRS and induced location memory impairment but did not affect pattern separation function",
      "experimental_conditions": "DREADD-mediated silencing of grafted interneurons"
    }
  ],
  "comparison_id": "mge-transplant-efficacy-across-disease-models",
  "comparison_name": "MGE Progenitor Transplantation Efficacy Across Disease Models",
  "comparison_type": "convergent evidence",
  "what_it_reveals": "MGE-derived interneuron transplants consistently restore inhibition and improve function across multiple disease models (epilepsy, psychosis, TBI), with direct evidence from DREADD experiments that grafted cells are the effectors",
  "homogeneity_check": {
    "caveats": [
      "Different disease models (MTLE, psychosis, TBI)",
      "Different brain regions (hippocampus vs visual cortex)",
      "Mouse vs rat species",
      "Embryonic mouse MGE vs human ESC-derived MGE interneurons",
      "Outcome metrics differ: seizure freedom vs synaptic inhibition vs cognitive function"
    ],
    "n_definition_uniform": "false",
    "scope_region_uniform": "false",
    "taxonomic_level_uniform": "true",
    "scope_population_uniform": "true"
  },
  "suggested_plot_type": "grouped bar"
}

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  "paper:paper-712ce855dc22",
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