Version history

{
  "kind": "infographic",
  "prompt": "MGE-derived interneuron transplants consistently restore inhibition and improve function across multiple disease models (epilepsy, psychosis, TBI), with direct evidence from DREADD experiments that grafted cells are the effectors",
  "provider": "other",
  "raw_fields": {
    "papers": [
      {
        "n": 0,
        "doi": "10.1016/j.stem.2023.08.013",
        "value": "most animals seizure-free",
        "method": "continuous video-EEG monitoring",
        "metric": "Seizure suppression rate after MGE interneuron transplant",
        "n_analyzed": null,
        "ci_or_error": null,
        "text_access": "fulltext",
        "n_definition": "animals per treatment group",
        "scope_region": "hippocampus",
        "study_system": "mouse MTLE model, human ESC-derived MGE interneurons",
        "taxonomic_level": "GABAergic interneurons",
        "scope_population": "transplanted MGE interneurons",
        "value_source_sentence": "Single-dose intrahippocampal delivery of the interneurons in a mouse model of chronic MTLE resulted in consistent mesiotemporal seizure suppression, with most animals becoming seizure-free and surviving longer.",
        "experimental_conditions": "single intrahippocampal injection, chronic MTLE"
      },
      {
        "n": 0,
        "doi": "10.1073/pnas.1316488111",
        "value": "mitigation of PV deficits, cognitive deficits, and dopamine dysregulation",
        "method": "in vivo electrophysiology, behavioral testing",
        "metric": "Reversal of hippocampal disinhibition and psychosis-like features after MGE transplant",
        "n_analyzed": null,
        "ci_or_error": null,
        "text_access": "fulltext",
        "n_definition": "animals per group",
        "scope_region": "hippocampus",
        "study_system": "mouse, Ccnd2-null psychosis model",
        "taxonomic_level": "GABAergic interneurons",
        "scope_population": "transplanted MGE interneurons",
        "value_source_sentence": "Transplanting interneuron progenitors derived from the embryonic medial ganglionic eminence into adult hippocampus mitigates these abnormalities.",
        "experimental_conditions": "adult hippocampal transplantation"
      },
      {
        "n": 0,
        "doi": "10.1093/pnasnexus/pgaf077",
        "value": "significant increases in synaptic inhibition",
        "method": "whole-cell voltage-clamp recordings",
        "metric": "Synaptic inhibition restoration after MGE transplant into injured visual cortex",
        "n_analyzed": null,
        "ci_or_error": null,
        "text_access": "fulltext",
        "n_definition": "neurons recorded",
        "scope_region": "visual cortex",
        "study_system": "mouse, traumatic brain injury model",
        "taxonomic_level": "GABAergic interneurons",
        "scope_population": "host L2/3 neurons receiving grafted interneuron input",
        "value_source_sentence": "Following MGE transplantation, we found significant increases in synaptic inhibition in regions of visual cortex containing transplanted MGE progenitors.",
        "experimental_conditions": "MGE transplant 45-60 days post-injury"
      },
      {
        "n": 0,
        "doi": "10.1038/s41536-022-00234-7",
        "value": "silencing graft-derived interneurons increased seizures and impaired location memory",
        "method": "chemogenetic silencing, seizure monitoring, behavioral testing",
        "metric": "Direct functional regulation by grafted interneurons (DREADD silencing reversal)",
        "n_analyzed": null,
        "ci_or_error": null,
        "text_access": "fulltext",
        "n_definition": "animals per group",
        "scope_region": "hippocampus",
        "study_system": "rat, chronic TLE, hPSC-derived MGE interneurons",
        "taxonomic_level": "GABAergic interneurons",
        "scope_population": "grafted MGE-like interneurons",
        "value_source_sentence": "silencing of graft-derived interneurons with a designer drug increased SRS and induced location memory impairment but did not affect pattern separation function",
        "experimental_conditions": "DREADD-mediated silencing of grafted interneurons"
      }
    ],
    "comparison_id": "mge-transplant-efficacy-across-disease-models",
    "comparison_name": "MGE Progenitor Transplantation Efficacy Across Disease Models",
    "comparison_type": "convergent evidence",
    "what_it_reveals": "MGE-derived interneuron transplants consistently restore inhibition and improve function across multiple disease models (epilepsy, psychosis, TBI), with direct evidence from DREADD experiments that grafted cells are the effectors",
    "homogeneity_check": {
      "caveats": [
        "Different disease models (MTLE, psychosis, TBI)",
        "Different brain regions (hippocampus vs visual cortex)",
        "Mouse vs rat species",
        "Embryonic mouse MGE vs human ESC-derived MGE interneurons",
        "Outcome metrics differ: seizure freedom vs synaptic inhibition vs cognitive function"
      ],
      "n_definition_uniform": "false",
      "scope_region_uniform": "false",
      "taxonomic_level_uniform": "true",
      "scope_population_uniform": "true"
    },
    "suggested_plot_type": "grouped bar"
  },
  "section_id": "section_03_evidence_package",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_03_evidence_package.json",
  "target_ref": "wiki_page:computationalreviewpv-03",
  "review_repo": "ComputationalReviewPV",
  "section_ref": "wiki_page:computationalreviewpv-03",
  "source_path": "evidence/section_03_evidence_package.json",
  "source_refs": [
    "paper:paper-0e26a6bda774",
    "paper:paper-1fadfb26d6f9",
    "paper:paper-712ce855dc22",
    "paper:paper-a5fa0281e9b3"
  ],
  "section_title": "Developmental Origins: MGE Lineage, Specification, and Migration",
  "source_policy": {
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    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
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  "generation_status": "complete",
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  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_03_evidence_package.json",
  "commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
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}