VIP→SST Disinhibitory Circuit Engagement Across Cortical Areas and Contexts

{
  "papers": [
    {
      "doi": "10.1038/nature12676",
      "value": "VIP preferentially inhibits SST across auditory, mPFC, visual cortex",
      "method": "in vivo electrophysiology and optogenetics",
      "metric": "VIP-SST disinhibition engagement",
      "cite_key": "Pi2013",
      "condition": "reward/punishment signals",
      "study_system": "mouse auditory, mPFC, visual cortex",
      "value_source_sentence": "Cortical interneurons that specialize in disinhibitory control"
    },
    {
      "doi": "10.1016/j.cell.2014.01.050",
      "value": "Locomotion activates VIP which inhibits SST and disinhibits pyramidal cells",
      "method": "in vivo calcium imaging",
      "metric": "VIP-SST engagement during locomotion",
      "cite_key": "Fu2014",
      "condition": "locomotion",
      "study_system": "mouse V1",
      "value_source_sentence": "locomotion activates VIP interneurons, which inhibit a second class of interneurons, the somatostatin (SST) cells, resulting in disinhibition"
    },
    {
      "doi": "10.1016/j.neuron.2018.03.037",
      "value": "Disinhibitory model fails when visual stimulation is added to locomotion",
      "method": "in vivo two-photon imaging and modeling",
      "metric": "Disinhibition model failure with visual stimulation",
      "cite_key": "Dipoppa2018",
      "condition": "locomotion + visual stimulation",
      "study_system": "mouse V1",
      "value_source_sentence": "the disinhibitory model failed when visual stimulation was added to locomotion"
    },
    {
      "doi": "10.1101/2022.11.28.518253",
      "value": "Attention and VIP disinhibition are orthogonal (non-interacting)",
      "method": "all-optical methods with attention task",
      "metric": "Attention vs disinhibition interaction",
      "cite_key": "MyersJoseph2022",
      "condition": "attention task",
      "study_system": "mouse V1",
      "value_source_sentence": "their effects were orthogonal"
    },
    {
      "doi": "10.1523/jneurosci.1369-21.2021",
      "value": "VIP→SST disinhibition gates LTP in piriform cortex",
      "method": "in vitro optogenetics",
      "metric": "VIP-SST disinhibition in olfactory cortex",
      "cite_key": "CantoBustos2022",
      "condition": "LTP induction",
      "study_system": "mouse piriform cortex",
      "value_source_sentence": "VIP interneurons strongly inhibit putative SST cells during LTP induction"
    },
    {
      "doi": "10.1016/j.neuron.2024.02.008",
      "value": "Behavioral strategy determines VIP-SST circuit engagement",
      "method": "in vivo imaging and behavior",
      "metric": "Strategy-dependent VIP-SST engagement",
      "cite_key": "Piet2024",
      "condition": "different behavioral strategies",
      "study_system": "mouse cortex",
      "value_source_sentence": "Behavioral strategy shapes activation of the Vip-Sst disinhibitory circuit"
    }
  ],
  "comparison_id": "vip-sst-disinhibition-across-areas",
  "comparison_name": "VIP→SST Disinhibitory Circuit Engagement Across Cortical Areas and Contexts",
  "comparison_type": "cross-study conflict",
  "what_it_reveals": "The VIP→SST disinhibition motif is found across cortical areas but its engagement varies with behavioral context, challenging the notion of a universal, always-active disinhibitory module.",
  "homogeneity_check": {
    "caveats": [
      "Different cortical areas",
      "Different behavioral paradigms",
      "Mix of in vivo and in vitro",
      "Different metrics for disinhibition strength"
    ],
    "comparable": false
  },
  "suggested_plot_type": "grouped bar"
}

[
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  "paper:paper-28660a26542f",
  "paper:paper-5cfe39bf225d",
  "paper:paper-918426c8bc54",
  "paper:pmid:38447579",
  "paper:paper-f457e091013f"
]

{
  "mode": "public_source_pointer_with_short_context",
  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
  ],
  "source_commit_sha": "89b7e9787cd90e942b0adb531d549af3ddad30f1",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewSST"
}