Version history

{
  "kind": "infographic",
  "prompt": "The VIP→SST disinhibition motif is found across cortical areas but its engagement varies with behavioral context, challenging the notion of a universal, always-active disinhibitory module.",
  "provider": "other",
  "raw_fields": {
    "papers": [
      {
        "doi": "10.1038/nature12676",
        "value": "VIP preferentially inhibits SST across auditory, mPFC, visual cortex",
        "method": "in vivo electrophysiology and optogenetics",
        "metric": "VIP-SST disinhibition engagement",
        "cite_key": "Pi2013",
        "condition": "reward/punishment signals",
        "study_system": "mouse auditory, mPFC, visual cortex",
        "value_source_sentence": "Cortical interneurons that specialize in disinhibitory control"
      },
      {
        "doi": "10.1016/j.cell.2014.01.050",
        "value": "Locomotion activates VIP which inhibits SST and disinhibits pyramidal cells",
        "method": "in vivo calcium imaging",
        "metric": "VIP-SST engagement during locomotion",
        "cite_key": "Fu2014",
        "condition": "locomotion",
        "study_system": "mouse V1",
        "value_source_sentence": "locomotion activates VIP interneurons, which inhibit a second class of interneurons, the somatostatin (SST) cells, resulting in disinhibition"
      },
      {
        "doi": "10.1016/j.neuron.2018.03.037",
        "value": "Disinhibitory model fails when visual stimulation is added to locomotion",
        "method": "in vivo two-photon imaging and modeling",
        "metric": "Disinhibition model failure with visual stimulation",
        "cite_key": "Dipoppa2018",
        "condition": "locomotion + visual stimulation",
        "study_system": "mouse V1",
        "value_source_sentence": "the disinhibitory model failed when visual stimulation was added to locomotion"
      },
      {
        "doi": "10.1101/2022.11.28.518253",
        "value": "Attention and VIP disinhibition are orthogonal (non-interacting)",
        "method": "all-optical methods with attention task",
        "metric": "Attention vs disinhibition interaction",
        "cite_key": "MyersJoseph2022",
        "condition": "attention task",
        "study_system": "mouse V1",
        "value_source_sentence": "their effects were orthogonal"
      },
      {
        "doi": "10.1523/jneurosci.1369-21.2021",
        "value": "VIP→SST disinhibition gates LTP in piriform cortex",
        "method": "in vitro optogenetics",
        "metric": "VIP-SST disinhibition in olfactory cortex",
        "cite_key": "CantoBustos2022",
        "condition": "LTP induction",
        "study_system": "mouse piriform cortex",
        "value_source_sentence": "VIP interneurons strongly inhibit putative SST cells during LTP induction"
      },
      {
        "doi": "10.1016/j.neuron.2024.02.008",
        "value": "Behavioral strategy determines VIP-SST circuit engagement",
        "method": "in vivo imaging and behavior",
        "metric": "Strategy-dependent VIP-SST engagement",
        "cite_key": "Piet2024",
        "condition": "different behavioral strategies",
        "study_system": "mouse cortex",
        "value_source_sentence": "Behavioral strategy shapes activation of the Vip-Sst disinhibitory circuit"
      }
    ],
    "comparison_id": "vip-sst-disinhibition-across-areas",
    "comparison_name": "VIP→SST Disinhibitory Circuit Engagement Across Cortical Areas and Contexts",
    "comparison_type": "cross-study conflict",
    "what_it_reveals": "The VIP→SST disinhibition motif is found across cortical areas but its engagement varies with behavioral context, challenging the notion of a universal, always-active disinhibitory module.",
    "homogeneity_check": {
      "caveats": [
        "Different cortical areas",
        "Different behavioral paradigms",
        "Mix of in vivo and in vitro",
        "Different metrics for disinhibition strength"
      ],
      "comparable": false
    },
    "suggested_plot_type": "grouped bar"
  },
  "section_id": "section_07_evidence_package",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewSST/blob/89b7e9787cd90e942b0adb531d549af3ddad30f1/evidence/section_07_evidence_package.json",
  "target_ref": "wiki_page:computationalreviewsst-07",
  "review_repo": "ComputationalReviewSST",
  "section_ref": "wiki_page:computationalreviewsst-07",
  "source_path": "evidence/section_07_evidence_package.json",
  "source_refs": [
    "paper:paper-065a0eae69a5",
    "paper:paper-28660a26542f",
    "paper:paper-5cfe39bf225d",
    "paper:paper-918426c8bc54",
    "paper:pmid:38447579",
    "paper:paper-f457e091013f"
  ],
  "section_title": "Circuit Motifs and Dendritic Computation",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "89b7e9787cd90e942b0adb531d549af3ddad30f1",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewSST"
  },
  "generation_status": "complete",
  "review_bundle_ref": "analysis_bundle:ab-8466d095488a",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewSST/blob/89b7e9787cd90e942b0adb531d549af3ddad30f1/evidence/section_07_evidence_package.json",
  "commit_sha": "89b7e9787cd90e942b0adb531d549af3ddad30f1",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewSST"
}