SST-Mediated Gain Control: Subtractive vs Divisive Operations

{
  "papers": [
    {
      "doi": "10.1038/nature11347",
      "value": "Subtractive inhibition by SST, divisive by PV",
      "method": "optogenetics + electrophysiology",
      "metric": "Gain operation type",
      "cite_key": "Wilson2012",
      "condition": "V1, anesthetized",
      "study_system": "mouse",
      "value_source_sentence": "Division and subtraction by distinct cortical inhibitory networks in vivo."
    },
    {
      "doi": "10.1038/nature11312",
      "value": "SST activation sharpens orientation tuning",
      "method": "optogenetics + behavior",
      "metric": "Feature selectivity improvement",
      "cite_key": "Lee2012",
      "condition": "V1, awake behaving",
      "study_system": "mouse",
      "value_source_sentence": "Activation of specific interneurons improves V1 feature selectivity and visual perception."
    },
    {
      "doi": "10.1016/j.neuron.2017.08.014",
      "value": "Condition-dependent gain operations",
      "method": "optogenetics + electrophysiology",
      "metric": "Gain operation type",
      "cite_key": "Adesnik2017",
      "condition": "V1, awake",
      "study_system": "mouse",
      "value_source_sentence": "Synaptic Mechanisms of Feature Coding in the Visual Cortex of Awake Mice."
    }
  ],
  "comparison_id": "sst-gain-control-mechanism",
  "comparison_name": "SST-Mediated Gain Control: Subtractive vs Divisive Operations",
  "comparison_type": "cross-study conflict",
  "what_it_reveals": "The ongoing debate about whether SST interneurons perform subtractive or divisive gain control, with resolution likely depending on experimental conditions.",
  "homogeneity_check": {
    "caveats": [
      "Anesthetized vs awake preparations produce different gain operations",
      "Different stimulation intensities and durations used",
      "Some studies used LED illumination, others fiber-coupled lasers"
    ],
    "comparable": false
  },
  "suggested_plot_type": "forest plot"
}

[
  "paper:paper-0539949fe271",
  "paper:paper-24fb0b34620e",
  "paper:paper-89a90cbbebc9"
]

{
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  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
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  "source_commit_sha": "89b7e9787cd90e942b0adb531d549af3ddad30f1",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewSST"
}