Version history

{
  "kind": "infographic",
  "prompt": "The ongoing debate about whether SST interneurons perform subtractive or divisive gain control, with resolution likely depending on experimental conditions.",
  "provider": "other",
  "raw_fields": {
    "papers": [
      {
        "doi": "10.1038/nature11347",
        "value": "Subtractive inhibition by SST, divisive by PV",
        "method": "optogenetics + electrophysiology",
        "metric": "Gain operation type",
        "cite_key": "Wilson2012",
        "condition": "V1, anesthetized",
        "study_system": "mouse",
        "value_source_sentence": "Division and subtraction by distinct cortical inhibitory networks in vivo."
      },
      {
        "doi": "10.1038/nature11312",
        "value": "SST activation sharpens orientation tuning",
        "method": "optogenetics + behavior",
        "metric": "Feature selectivity improvement",
        "cite_key": "Lee2012",
        "condition": "V1, awake behaving",
        "study_system": "mouse",
        "value_source_sentence": "Activation of specific interneurons improves V1 feature selectivity and visual perception."
      },
      {
        "doi": "10.1016/j.neuron.2017.08.014",
        "value": "Condition-dependent gain operations",
        "method": "optogenetics + electrophysiology",
        "metric": "Gain operation type",
        "cite_key": "Adesnik2017",
        "condition": "V1, awake",
        "study_system": "mouse",
        "value_source_sentence": "Synaptic Mechanisms of Feature Coding in the Visual Cortex of Awake Mice."
      }
    ],
    "comparison_id": "sst-gain-control-mechanism",
    "comparison_name": "SST-Mediated Gain Control: Subtractive vs Divisive Operations",
    "comparison_type": "cross-study conflict",
    "what_it_reveals": "The ongoing debate about whether SST interneurons perform subtractive or divisive gain control, with resolution likely depending on experimental conditions.",
    "homogeneity_check": {
      "caveats": [
        "Anesthetized vs awake preparations produce different gain operations",
        "Different stimulation intensities and durations used",
        "Some studies used LED illumination, others fiber-coupled lasers"
      ],
      "comparable": false
    },
    "suggested_plot_type": "forest plot"
  },
  "section_id": "section_08_evidence_package",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewSST/blob/89b7e9787cd90e942b0adb531d549af3ddad30f1/evidence/section_08_evidence_package.json",
  "target_ref": "wiki_page:computationalreviewsst-08",
  "review_repo": "ComputationalReviewSST",
  "section_ref": "wiki_page:computationalreviewsst-08",
  "source_path": "evidence/section_08_evidence_package.json",
  "source_refs": [
    "paper:paper-0539949fe271",
    "paper:paper-24fb0b34620e",
    "paper:paper-89a90cbbebc9"
  ],
  "section_title": "In Vivo Function During Behavior",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "89b7e9787cd90e942b0adb531d549af3ddad30f1",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewSST"
  },
  "generation_status": "complete",
  "review_bundle_ref": "analysis_bundle:ab-8466d095488a",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewSST/blob/89b7e9787cd90e942b0adb531d549af3ddad30f1/evidence/section_08_evidence_package.json",
  "commit_sha": "89b7e9787cd90e942b0adb531d549af3ddad30f1",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewSST"
}