Serotonin modulation of neural activity across brain regions

{
  "title": "Serotonin modulation of neural activity across brain regions",
  "papers": [
    {
      "doi": "10.1101/2025.10.24.684353",
      "value": "90%",
      "n_definition": "neurons or recordings",
      "scope_region": "prefrontal cortex",
      "scope_population": "neurons",
      "value_source_sentence": "), but strongly (90%) increased in the 2-5 h time bin, an effect abolished by lesioning the mPFC or administering the mTOR inhibitor Torin-2."
    },
    {
      "doi": "10.1038/s41380-025-03182-y",
      "value": "100 Hz",
      "n_definition": "neurons or recordings",
      "scope_region": "prefrontal cortex",
      "scope_population": "neurons",
      "value_source_sentence": ") unmasked 100 Hz high frequency oscillations that were most pronounced within the infralimbic cortex, persisted for approximately 1 h post-injection and were accompanied by decreased net neuronal firing rates and reduced spike-train complexity."
    },
    {
      "doi": "10.3390/biom15111603",
      "value": "62.96%",
      "n_definition": "neurons or recordings",
      "scope_region": "hippocampus",
      "scope_population": "neurons",
      "value_source_sentence": " Persistent firing was observed in 62.96% of SLM neurons and was abolished by ML218 or olanzapine."
    },
    {
      "doi": "10.1111/fcp.70043",
      "value": "33%",
      "n_definition": "neurons or recordings",
      "scope_region": "amygdala",
      "scope_population": "neurons",
      "value_source_sentence": " Our review reveals the techniques' significant contributions across different research domains, including physiological (33%), pathological (53%), and dual-purpose studies (13%)."
    },
    {
      "doi": "10.1210/endocr/bqag034",
      "value": "60%",
      "n_definition": "neurons or recordings",
      "scope_region": "dorsal raphe",
      "scope_population": "neurons",
      "value_source_sentence": " Acute brain slice electrophysiology revealed that ∼60% of ARNKISS neurons in diestrous female mice were activated by serotonin while less than 10% were inhibited."
    },
    {
      "doi": "10.1101/2025.10.24.684353",
      "value": "90%",
      "n_definition": "neurons or recordings",
      "scope_region": "dorsal raphe",
      "scope_population": "neurons",
      "value_source_sentence": "), but strongly (90%) increased in the 2-5 h time bin, an effect abolished by lesioning the mPFC or administering the mTOR inhibitor Torin-2."
    }
  ],
  "figure_id": "fig_sec6_5ht_regional_modulation",
  "n_analyzed": null,
  "description": "Comparison of 5-HT effects on neural firing rates or excitability across different brain regions, showing region-specific modulation patterns.",
  "comparison_type": "cross-regional comparison",
  "taxonomic_level": "brain region",
  "homogeneity_check": {
    "caveats": [
      "Different studies use different recording techniques (in vivo vs slice)",
      "Different 5-HT concentrations/stimulation parameters across studies",
      "Species differ across studies (mouse, rat, human)",
      "Cell types recorded vary (pyramidal, interneurons, projection neurons)",
      "Effect sizes reported in different units (Hz, %, fold-change)"
    ],
    "comparable": false
  }
}

[
  "paper:paper-0214ce4fa8d6",
  "paper:paper-03364afa2055",
  "paper:paper-0e80ec8eaa34",
  "paper:paper-5374de1d843e",
  "paper:paper-abd25ce14a38"
]

{
  "mode": "public_source_pointer_with_short_context",
  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
  ],
  "source_commit_sha": "95db5c630fe54e183d9c452cf826ce502d4a872d",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewNeuromodulation"
}