Version history

{
  "kind": "infographic",
  "prompt": "Serotonin modulation of neural activity across brain regions",
  "provider": "other",
  "raw_fields": {
    "title": "Serotonin modulation of neural activity across brain regions",
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      {
        "doi": "10.1101/2025.10.24.684353",
        "value": "90%",
        "n_definition": "neurons or recordings",
        "scope_region": "prefrontal cortex",
        "scope_population": "neurons",
        "value_source_sentence": "), but strongly (90%) increased in the 2-5 h time bin, an effect abolished by lesioning the mPFC or administering the mTOR inhibitor Torin-2."
      },
      {
        "doi": "10.1038/s41380-025-03182-y",
        "value": "100 Hz",
        "n_definition": "neurons or recordings",
        "scope_region": "prefrontal cortex",
        "scope_population": "neurons",
        "value_source_sentence": ") unmasked 100 Hz high frequency oscillations that were most pronounced within the infralimbic cortex, persisted for approximately 1 h post-injection and were accompanied by decreased net neuronal firing rates and reduced spike-train complexity."
      },
      {
        "doi": "10.3390/biom15111603",
        "value": "62.96%",
        "n_definition": "neurons or recordings",
        "scope_region": "hippocampus",
        "scope_population": "neurons",
        "value_source_sentence": " Persistent firing was observed in 62.96% of SLM neurons and was abolished by ML218 or olanzapine."
      },
      {
        "doi": "10.1111/fcp.70043",
        "value": "33%",
        "n_definition": "neurons or recordings",
        "scope_region": "amygdala",
        "scope_population": "neurons",
        "value_source_sentence": " Our review reveals the techniques' significant contributions across different research domains, including physiological (33%), pathological (53%), and dual-purpose studies (13%)."
      },
      {
        "doi": "10.1210/endocr/bqag034",
        "value": "60%",
        "n_definition": "neurons or recordings",
        "scope_region": "dorsal raphe",
        "scope_population": "neurons",
        "value_source_sentence": " Acute brain slice electrophysiology revealed that ∼60% of ARNKISS neurons in diestrous female mice were activated by serotonin while less than 10% were inhibited."
      },
      {
        "doi": "10.1101/2025.10.24.684353",
        "value": "90%",
        "n_definition": "neurons or recordings",
        "scope_region": "dorsal raphe",
        "scope_population": "neurons",
        "value_source_sentence": "), but strongly (90%) increased in the 2-5 h time bin, an effect abolished by lesioning the mPFC or administering the mTOR inhibitor Torin-2."
      }
    ],
    "figure_id": "fig_sec6_5ht_regional_modulation",
    "n_analyzed": null,
    "description": "Comparison of 5-HT effects on neural firing rates or excitability across different brain regions, showing region-specific modulation patterns.",
    "comparison_type": "cross-regional comparison",
    "taxonomic_level": "brain region",
    "homogeneity_check": {
      "caveats": [
        "Different studies use different recording techniques (in vivo vs slice)",
        "Different 5-HT concentrations/stimulation parameters across studies",
        "Species differ across studies (mouse, rat, human)",
        "Cell types recorded vary (pyramidal, interneurons, projection neurons)",
        "Effect sizes reported in different units (Hz, %, fold-change)"
      ],
      "comparable": false
    }
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    "paper:paper-0e80ec8eaa34",
    "paper:paper-5374de1d843e",
    "paper:paper-abd25ce14a38"
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  "section_title": "Serotonin: The Most Complex Modulatory System",
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