PL vs IL roles in drug seeking: Evidence from inactivation studies

{
  "title": "PL vs IL roles in drug seeking: Evidence from inactivation studies",
  "papers": [
    {
      "doi": "10.1523/JNEUROSCI.1291-15.2016",
      "value": "PL inactivation reduces reinstatement",
      "method": "pharmacological inactivation",
      "cite_key": "McGlinchey2016",
      "study_system": "rat",
      "value_source_sentence": "Inactivation studies consistently show that prelimbic cortex activity is required for reinstatement of cocaine seeking."
    },
    {
      "doi": "10.1007/s00213-012-2762-5",
      "value": "IL activation promotes extinction",
      "method": "optogenetic/pharmacological",
      "cite_key": "Ball2012",
      "study_system": "rat",
      "value_source_sentence": "Infralimbic cortex activation is associated with suppression of drug seeking and promotion of extinction learning."
    }
  ],
  "x_axis": "Brain region (PL, IL) x Condition (seeking, extinction)",
  "y_axis": "Effect on drug seeking (increase/decrease)",
  "figure_id": "fig_sec2_pfc_reinstatement",
  "n_analyzed": "typically 8-15 per group",
  "n_definition": "animals per experimental group",
  "scope_region": "medial prefrontal cortex (PL and IL)",
  "source_cluster": 1,
  "comparison_type": "functional dissociation comparison",
  "taxonomic_level": "subregion-level",
  "scope_population": "pyramidal neurons (primarily)",
  "homogeneity_check": "Limited comparability. Studies use different drugs (cocaine, heroin, methamphetamine), different manipulation methods (muscimol, optogenetics, DREADDs), different reinstatement models (cue, context, drug-primed, stress), and different behavioral readouts. The PL=seeking/IL=extinction dichotomy was established primarily with cocaine; it may not hold for other drugs or reinstatement triggers."
}

[
  "paper:paper-b48c5fedf92e",
  "paper:paper-c5e244bd01e5"
]

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