Version history

{
  "kind": "infographic",
  "prompt": "PL vs IL roles in drug seeking: Evidence from inactivation studies",
  "provider": "other",
  "raw_fields": {
    "title": "PL vs IL roles in drug seeking: Evidence from inactivation studies",
    "papers": [
      {
        "doi": "10.1523/JNEUROSCI.1291-15.2016",
        "value": "PL inactivation reduces reinstatement",
        "method": "pharmacological inactivation",
        "cite_key": "McGlinchey2016",
        "study_system": "rat",
        "value_source_sentence": "Inactivation studies consistently show that prelimbic cortex activity is required for reinstatement of cocaine seeking."
      },
      {
        "doi": "10.1007/s00213-012-2762-5",
        "value": "IL activation promotes extinction",
        "method": "optogenetic/pharmacological",
        "cite_key": "Ball2012",
        "study_system": "rat",
        "value_source_sentence": "Infralimbic cortex activation is associated with suppression of drug seeking and promotion of extinction learning."
      }
    ],
    "x_axis": "Brain region (PL, IL) x Condition (seeking, extinction)",
    "y_axis": "Effect on drug seeking (increase/decrease)",
    "figure_id": "fig_sec2_pfc_reinstatement",
    "n_analyzed": "typically 8-15 per group",
    "n_definition": "animals per experimental group",
    "scope_region": "medial prefrontal cortex (PL and IL)",
    "source_cluster": 1,
    "comparison_type": "functional dissociation comparison",
    "taxonomic_level": "subregion-level",
    "scope_population": "pyramidal neurons (primarily)",
    "homogeneity_check": "Limited comparability. Studies use different drugs (cocaine, heroin, methamphetamine), different manipulation methods (muscimol, optogenetics, DREADDs), different reinstatement models (cue, context, drug-primed, stress), and different behavioral readouts. The PL=seeking/IL=extinction dichotomy was established primarily with cocaine; it may not hold for other drugs or reinstatement triggers."
  },
  "section_id": "section_12_evidence",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewAddiction/blob/43d33061a22aa4fed3f7dc71fabbfa48ab1d6f48/evidence/section_12_evidence.json",
  "target_ref": "wiki_page:computationalreviewaddiction-12",
  "review_repo": "ComputationalReviewAddiction",
  "section_ref": "wiki_page:computationalreviewaddiction-12",
  "source_path": "evidence/section_12_evidence.json",
  "source_refs": [
    "paper:paper-b48c5fedf92e",
    "paper:paper-c5e244bd01e5"
  ],
  "section_title": "Synthesis: An Evidence Scorecard for Addiction Neuroscience",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "43d33061a22aa4fed3f7dc71fabbfa48ab1d6f48",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewAddiction"
  },
  "generation_status": "complete",
  "review_bundle_ref": "analysis_bundle:ab-d95cfb705572",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewAddiction/blob/43d33061a22aa4fed3f7dc71fabbfa48ab1d6f48/evidence/section_12_evidence.json",
  "commit_sha": "43d33061a22aa4fed3f7dc71fabbfa48ab1d6f48",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewAddiction"
}